Gut microbiota dynamics in travelers returning from India colonized with extended-spectrum cephalosporin-resistant Enterobacteriaceae: A longitudinal study.

Details

Serval ID
serval:BIB_2CABF8F0DF6C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gut microbiota dynamics in travelers returning from India colonized with extended-spectrum cephalosporin-resistant Enterobacteriaceae: A longitudinal study.
Journal
Travel medicine and infectious disease
Author(s)
Pires J., Kraemer J.G., Kuenzli E., Kasraian S., Tinguely R., Hatz C., Endimiani A., Hilty M.
ISSN
1873-0442 (Electronic)
ISSN-L
1477-8939
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
27
Pages
72-80
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Intestinal colonization by extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESC-R-Ent) has been attributed to travel to high prevalence countries. However, the dynamics of the microbiota changes during ESC-R-Ent colonization and whether there is a particular bacterial composition which is associated with subsequent colonization is unknown.
Forty healthy volunteers living in Switzerland underwent screening before and after a trip to India, and also 3, 6 and 12 months after traveling. Culture-based ESC-R-Ent screening and microbiota analysis based on 16S rRNA amplicon sequencing were performed at all time points.
Prevalence of ESC-R-Ent colonization before traveling was 10% (n = 4), whereas it increased to 76% (n = 31) after the trip. Based on bacterial diversity analyses of the gut microbiota, there were few but significant differences for colonized versus non-colonized individuals. However, an alternative, cluster based analysis revealed that individuals remained in the same cluster over time indicating that neither traveling nor ESC-R-Ent colonization significantly influences bacterial composition. Moreover, none of the found microbiota clusters were significantly associated with subsequent risk of ESC-R-Ent colonization.
Based on their microbiota patterns, every volunteer was at the same risk of ESC-R-Ent colonization while traveling to India. Therefore, other risk factors for ESC-R-Ent colonization are responsible for this phenomenon.
Keywords
Adult, Aged, Anti-Bacterial Agents/pharmacology, Cephalosporins/pharmacology, Cluster Analysis, Drug Resistance, Multiple, Bacterial, Enterobacteriaceae/drug effects, Enterobacteriaceae/genetics, Enterobacteriaceae Infections/epidemiology, Feces/microbiology, Female, Gastrointestinal Microbiome, Healthy Volunteers, Humans, India, Longitudinal Studies, Male, Middle Aged, Prevalence, Prospective Studies, RNA, Ribosomal, 16S/genetics, Switzerland, Time Factors, Travel-Related Illness, Antimicrobial resistance, ESBL, Intestinal colonization, MDR bacteria, Microbiota, Travel
Pubmed
Web of science
Create date
05/11/2018 9:34
Last modification date
20/08/2019 13:11
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