Macrophage migration inhibitory factor: a regulator of innate immunity.

Details

Serval ID
serval:BIB_2CA3902B3091
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Macrophage migration inhibitory factor: a regulator of innate immunity.
Journal
Nature reviews. Immunology
Author(s)
Calandra T., Roger T.
ISSN
1474-1733
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
3
Number
10
Pages
791-800
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Abstract
For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal regulator of innate immunity. MIF is an integral component of the host antimicrobial alarm system and stress response that promotes the pro-inflammatory functions of immune cells. A rapidly increasing amount of literature indicates that MIF is implicated in the pathogenesis of sepsis, and inflammatory and autoimmune diseases, suggesting that MIF-directed therapies might offer new treatment opportunities for human diseases in the future.
Keywords
Animals, Autoimmune Diseases, Humans, Immunity, Innate, Inflammation, Macrophage Migration-Inhibitory Factors, Macrophages, Sepsis
Pubmed
Web of science
Create date
25/01/2008 13:35
Last modification date
20/08/2019 13:11
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