BOLD responses to trigeminal nerve stimulation.

Details

Serval ID
serval:BIB_2CA18165F9D2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
BOLD responses to trigeminal nerve stimulation.
Journal
Magnetic Resonance Imaging
Author(s)
Just Nathalie, Petersen Carl, Gruetter Rolf
ISSN
1873-5894[electronic], 0730-725X[linking]
Publication state
Published
Issued date
2010
Volume
28
Number
8
Pages
1143-1151
Language
english
Abstract
The current study investigates a new model of barrel cortex activation using stimulation of the infraorbital branch of the trigeminal nerve. A robust and reproducible activation of the rat barrel cortex was obtained following trigeminal nerve stimulation. Blood oxygen level-dependent (BOLD) effects were obtained in the primary somatosensory barrel cortex (S1BF), the secondary somatosensory cortex (S2) and the motor cortex. These cortical areas were reached from afferent pathways from the trigeminal ganglion, the trigeminal nuclei and thalamic nuclei from which neurons project their axons upon whisker stimulation. The maximum BOLD responses were obtained for a stimulus frequency of 1 Hz, a stimulus pulse width of 100 μs and for current intensities between 1.5 and 3 mA. The BOLD response was nonlinear as a function of frequency and current intensity. Additionally, modeling BOLD responses in the rat barrel cortex from separate cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO(2)) measurements showed good agreement with the shape and amplitude of measured BOLD responses as a function of stimulus frequency and will potentially allow to identify the sources of BOLD nonlinearities. Activation of the rat barrel cortex using trigeminal nerve stimulation will contribute to the interpretation of the BOLD signals from functional magnetic resonance imaging studies.
Keywords
Trigeminal nerve, Barrel cortex, BOLD, Neurovascular coupling, Modeling, cerebral-blood-flow, rat somatosensory cortex, activity-dependent increases, magnetic-resonance, neuronal-activity, functional mri, barrel cortex, fmri signal, hemodynamic-response, sensorimotor system
Pubmed
Web of science
Create date
27/10/2010 12:43
Last modification date
20/08/2019 13:11
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