Effect of Platinum-Based Chemoradiotherapy on Cellular Proliferation in Bone Marrow and Spleen, Estimated by 18F-FLT PET/CT in Patients with Locally Advanced Non-Small Cell Lung Cancer.

Details

Serval ID
serval:BIB_2C43173CC4A7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of Platinum-Based Chemoradiotherapy on Cellular Proliferation in Bone Marrow and Spleen, Estimated by 18F-FLT PET/CT in Patients with Locally Advanced Non-Small Cell Lung Cancer.
Journal
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Author(s)
Leimgruber A., Möller A., Everitt S.J., Chabrot M., Ball D.L., Solomon B., MacManus M., Hicks R.J.
ISSN
1535-5667 (Electronic)
ISSN-L
0161-5505
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
55
Number
7
Pages
1075-1080
Language
english
Notes
Publication types: ARTICLE
Abstract
Historically, it has been difficult to monitor the acute impact of anticancer therapies on hematopoietic organs on a whole-body scale. Deeper understanding of the effect of treatments on bone marrow would be of great potential value in the rational design of intensive treatment regimens. 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) is a functional radiotracer used to study cellular proliferation. It is trapped in cells in proportion to thymidine-kinase 1 enzyme expression, which is upregulated during DNA synthesis. This study investigates the potential of (18)F-FLT to monitor acute effects of chemotherapy on cellular proliferation and its recovery in bone marrow, spleen, and liver during treatment with 2 different chemotherapy regimens.
Pubmed
Web of science
Open Access
Yes
Create date
08/08/2014 18:21
Last modification date
20/08/2019 13:11
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