Carcinoembryonic antigen (CEA): demonstration of a partial identity between CEA and a normal glycoprotein.

Details

Serval ID
serval:BIB_2C3D5FAF46C2
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
Carcinoembryonic antigen (CEA): demonstration of a partial identity between CEA and a normal glycoprotein.
Journal
Immunochemistry
Author(s)
Mach J.P., Pusztaszeri G.
ISSN
0019-2791 (Print)
ISSN-L
0019-2791
Publication state
Published
Issued date
1972
Volume
9
Number
10
Pages
1031-1034
Language
english
Abstract
The carcinoembryonic antigen of the human digestive tract (CEA), described by Gold as a glycoprotein specific for digestive carcinomatous and foetal tissues, was found to have common antigenic determinants with a glycoprotein of smaller size extracted from normal adult tissues. This observation suggests that only a part of the CEA molecule carries the onco-foetal specificity. It also has practical implications regarding the radioimmunoassay for CEA used for the diagnosis of certain carcinomas.
Keywords
Adenocarcinoma/diagnosis, Animals, Antigens, Neoplasm, Breast/immunology, Colonic Neoplasms/immunology, Epitopes, Gastrointestinal Neoplasms/diagnosis, Glycoproteins, Humans, Immunodiffusion, Immunoelectrophoresis, Intestines/immunology, Lung/immunology, Male, Prostate/immunology, Rabbits/immunology, Radioimmunoassay, Spleen/immunology
Pubmed
Web of science
Create date
24/04/2013 10:01
Last modification date
20/08/2019 13:11
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