Stereological analysis of the rhesus monkey entorhinal cortex.

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Serval ID
serval:BIB_2C3B609A5233
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Stereological analysis of the rhesus monkey entorhinal cortex.
Journal
The Journal of comparative neurology
Author(s)
Piguet O., Chareyron L.J., Banta Lavenex P., Amaral D.G., Lavenex P.
ISSN
1096-9861 (Electronic)
ISSN-L
0021-9967
Publication state
Published
Issued date
01/09/2018
Peer-reviewed
Oui
Volume
526
Number
13
Pages
2115-2132
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The entorhinal cortex is a prominent structure of the medial temporal lobe, which plays a pivotal role in the interaction between the neocortex and the hippocampal formation in support of declarative and spatial memory functions. We implemented design-based stereological techniques to provide estimates of neuron numbers, neuronal soma size, and volume of different layers and subdivisions of the entorhinal cortex in adult rhesus monkeys (Macaca mulatta; 5-9 years of age). These data corroborate the structural differences between different subdivisions of the entorhinal cortex, which were shown in previous connectional and cytoarchitectonic studies. In particular, differences in the number of neurons contributing to distinct afferent and efferent hippocampal pathways suggest not only that different types of information may be more or less segregated between caudal and rostral subdivisions, but also, and perhaps most importantly, that the nature of the interaction between the entorhinal cortex and the rest of the hippocampal formation may vary between different subdivisions. We compare our quantitative data in monkeys with previously published stereological data for the rat and human, in order to provide a perspective on the relative development and structural organization of the main subdivisions of the entorhinal cortex in two model organisms widely used to decipher the basic functional principles of the human medial temporal lobe memory system. Altogether, these data provide fundamental information on the number of functional units that comprise the entorhinal-hippocampal circuits and should be considered in order to build realistic models of the medial temporal lobe memory system.
Keywords
RRID:AB_2313581, RRID:AB_2314904, hippocampal formation, neurofilament, neuron number
Pubmed
Web of science
Create date
17/08/2018 20:10
Last modification date
13/10/2021 5:42
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