Acute hemodynamic effect of a vascular antagonist of vasopressin in patients with congestive heart failure.

Details

Serval ID
serval:BIB_2C3A9EB8C021
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acute hemodynamic effect of a vascular antagonist of vasopressin in patients with congestive heart failure.
Journal
American Journal of Cardiology
Author(s)
Nicod P., Waeber B., Bussien J.P., Goy J.J., Turini G., Nussberger J., Hofbauer K.G., Brunner H.R.
ISSN
0002-9149
Publication state
Published
Issued date
1985
Peer-reviewed
Oui
Volume
55
Number
8
Pages
1043-1047
Language
english
Notes
Publication types: Journal Article
Abstract
To assess the role of arginine vasopressin (AVP) in congestive heart failure (CHF), 10 patients with CHF refractory to conventional treatment were studied before and 60 minutes after intravenous administration of 5 micrograms/kg of d(CH2)5Tyr(Me)AVP, a specific antagonist of AVP at the vascular receptor level. Heart rate, systemic arterial pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, cardiac index by thermodilution and cutaneous blood flow by laser-Doppler technique were measured. In 9 patients with no significant hemodynamic and cutaneous blood flow response to the AVP antagonist, baseline values (mean +/- standard deviation) were: heart rate, 77 +/- 14 beats/min; systemic arterial pressure, 120/79 +/- 18/8 mm Hg; pulmonary arterial pressure, 42/21 +/- 12/8 mm Hg; pulmonary capillary wedge pressure, 19 +/- 7 mm Hg; cardiac index, 2.2 +/- 0.6 liters/min/m2; plasma AVP, 2.3 +/- 0.8 pg/ml; and plasma osmolality, 284 +/- 14 mosm/kg H2O. The tenth patient had the most severe CHF. His plasma AVP level was 55 pg/ml and plasma osmolality was 290 mosm/kg. He responded to the AVP antagonist with a decrease in systemic arterial pressure from 115/61 to 79/41 mm Hg, in pulmonary arterial pressure from 58/31 to 33/13 mm Hg and in pulmonary capillary wedge pressure from 28 to 15 mm Hg. Simultaneously, cardiac index increased from 1.1 to 2.2 liters/min/m2 and heart rate from 113 to 120 beats/min; cutaneous blood flow increased 5-fold.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Adult, Aged, Arginine Vasopressin, Blood Pressure, Cardiac Output, Epinephrine, Female, Heart Failure, Hemodynamics, Humans, Male, Middle Aged, Norepinephrine, Regional Blood Flow, Renin, Skin
Pubmed
Web of science
Create date
05/03/2008 16:41
Last modification date
20/08/2019 13:11
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