Renal effects of converting enzyme inhibition

Details

Serval ID
serval:BIB_2C177BD7E41C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Renal effects of converting enzyme inhibition
Journal
Journal of Cardiovascular Pharmacology
Author(s)
Brunner  H. R., Waeber  B., Nussberger  J.
ISSN
0160-2446 (Print)
Publication state
Published
Issued date
1987
Volume
9 Suppl 3
Pages
S6-14
Notes
Journal Article
Review
Abstract
Angiotensin-converting enzyme inhibition, by preventing the generation of angiotensin II, has some pronounced effects on renal function. Its actions occur at the vascular, the glomerular, the juxtaglomerular, and also at the tubular medullary level. In clinical medicine, depending on the circumstances of the patients under treatment, converting enzyme inhibitors can interfere with renal hemodynamics and glomerular filtration, with solute excretion by the kidney and other variables of normal renal function. In most circumstances, the effects of converting enzyme inhibition on the kidney are rather beneficial to the patient. However, under some extreme conditions, they may become potentially hazardous. A basic understanding of the physiology of the renin-angiotensin system and of its actions on the kidney makes it possible to understand the impact of the converting enzyme inhibitors, to avoid most of the unwanted effects and to ensure greatest benefit to the patient.
Keywords
*Angiotensin-Converting Enzyme Inhibitors Humans Kidney/*drug effects Renal Circulation/drug effects
Pubmed
Web of science
Create date
05/03/2008 17:40
Last modification date
20/08/2019 14:11
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