Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia.

Details

Serval ID
serval:BIB_2C0C551FFDA0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia.
Journal
Neuroscience
Author(s)
Paolicelli R.C., Bergamini G., Rajendran L.
ISSN
1873-7544 (Electronic)
ISSN-L
0306-4522
Publication state
Published
Issued date
01/05/2019
Peer-reviewed
Oui
Volume
405
Pages
148-157
Language
english
Notes
Publication types: Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Extracellular vesicles, including exosomes and microvesicles, are small, nano-to-micrometer vesicles that are released from cells. While initially observed in immune cells and reticulocytes as vesicles meant to remove archaic proteins, now they have been observed in almost all cell types of multicellular organisms. Growing evidence indicates that extracellular vesicles, containing lipids, proteins and RNAs, represent an efficient way to transfer functional cargoes from one cell to another. In the central nervous system, the extensive cross-talk ongoing between neurons and glia, including microglia, the immune cells of the brain, takes advantage of secreted vesicles, which mediate intercellular communication over long range distance. Recent literature supports a critical role for extracellular vesicles in mediating complex and coordinated communication among neurons, astrocytes and microglia, both in the healthy and in the diseased brain. In this review, we focus on the biogenesis and function of microglia-related extracellular vesicles and focus on their putative role in Alzheimer's disease pathology.
Keywords
Alzheimer’s disease, exosomes, extracellular vesicles, microglia, microvesicles, neurons
Pubmed
Web of science
Open Access
Yes
Create date
18/12/2018 11:55
Last modification date
20/08/2019 14:11
Usage data