Decreases in regional cerebral blood flow with normal aging.

Details

Serval ID
serval:BIB_2C0C3BFB390A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Decreases in regional cerebral blood flow with normal aging.
Journal
Journal of Cerebral Blood Flow and Metabolism
Author(s)
Martin A.J., Friston K.J., Colebatch J.G., Frackowiak R.S.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Publication state
Published
Issued date
1991
Volume
11
Number
4
Pages
684-689
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Positron emission tomographic (PET) images of regional cerebral blood flow (rCBF) from 30 normal, resting volunteers aged 30 to 85 years were analysed to identify areas where rCBF fell with age. Images were anatomically normalised, and a pixel-by-pixel linear regression was performed to remove differences in global CBF between subjects. Pixels at which rCBF then showed a significant (p less than 0.01) negative correlation with age were identified. They were displayed as a statistical parametric map (SPM) of correlations. We demonstrate an age-related decrease in adjusted rCBF in the cingulate, parahippocampal, superior temporal, medial frontal, and posterior parietal cortices bilaterally, and in the left insular and left posterior prefrontal cortices (omnibus significance, chi 2 = 2,291, p less than 0.0001, df = 1). Decreases in rCBF suggest a regionally specific loss of cerebral function with age. The affected areas were all limbic, or association, cortices. Therefore, these decreases may constitute the cerebral substrate of the cognitive changes that occur during normal aging.
Keywords
Adult, Aged, Aged, 80 and over, Aging/physiology, Blood Flow Velocity, Cerebrovascular Circulation/physiology, Female, Frontal Lobe/blood supply, Gyrus Cinguli/blood supply, Hippocampus/blood supply, Humans, Male, Middle Aged, Parietal Lobe/blood supply, Temporal Lobe/blood supply, Tomography, Emission-Computed
Pubmed
Web of science
Create date
25/09/2011 16:55
Last modification date
20/08/2019 13:11
Usage data