Boost radiotherapy in young women with ductal carcinoma in situ: a multicentre, retrospective study of the Rare Cancer Network

Details

Serval ID
serval:BIB_2BFB3FDC59F8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Boost radiotherapy in young women with ductal carcinoma in situ: a multicentre, retrospective study of the Rare Cancer Network
Journal
Lancet Oncology
Author(s)
Omlin  A., Amichetti  M., Azria  D., Cole  B. F., Fourneret  P., Poortmans  P., Naehrig  D., Miller  R. C., Krengli  M., Gutierrez Miguelez  C., Morgan  D., Goldberg  H., Scandolaro  L., Gastelblum  P., Ozsahin  M., Dohr  D., Christie  D., Oppitz  U., Abacioglu  U., Gruber  G.
ISSN
1470-2045
Publication state
Published
Issued date
08/2006
Peer-reviewed
Oui
Volume
7
Number
8
Pages
652-6
Notes
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural --- Old month value: Aug
Abstract
BACKGROUND: Outcome data in young women with ductal carcinoma in situ (DCIS) are rare. The benefits of boost radiotherapy in this group are also unknown. We aimed to assess the effect of boost radiotherapy in young patients with DCIS. METHODS: We included 373 women from 18 institutions who met the following inclusion criteria: having tumour status Tis and nodal status (N)0, age 45 years or younger at diagnosis, and having had breast-conserving surgery. 57 (15%) patients had no radiotherapy after surgery, 166 (45%) had radiotherapy without boost (median dose 50 Gy [range 40-60]), and 150 (40%) had radiotherapy with boost (60 Gy [53-76]). The primary outcome was local relapse-free survival. FINDINGS: Median follow-up was 72 months (range 1-281). 55 (15%) patients had local relapse. Local relapse-free survival at 10 years was 46% (95% CI 24-67) for patients given no radiotherapy, 72% (61-83) for those given radiotherapy without boost, and 86% (78-93) for those given radiotherapy and boost (difference between all three groups, p<0.0001). Age, margin status, and radiotherapy dose were significant predictors of local relapse-free survival. Compared with patients who had no radiotherapy, those who had radiotherapy had a decreased risk of local relapse (without boost, hazard ratio 0.33 [95% CI 0.16-0.71], p=0.004; with boost, 0.15 [0.06-0.36], p<0.0001). INTERPRETATION: In the absence of randomised trials, boost radiotherapy should be considered in addition to surgery for breast-conserving treatment for DCIS.
Keywords
Adult Breast Neoplasms/mortality/*radiotherapy/surgery Carcinoma, Ductal, Breast/mortality/*radiotherapy/surgery Disease-Free Survival Female Humans Lymphatic Metastasis/prevention & control Mastectomy Middle Aged Neoplasm Recurrence, Local/prevention & control Radiotherapy Dosage Retrospective Studies
Pubmed
Web of science
Create date
24/01/2008 17:16
Last modification date
20/08/2019 13:11
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