Hepatitis E virus infection as a direct cause of neuralgic amyotrophy.

Details

Serval ID
serval:BIB_2BF873E47ECA
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Hepatitis E virus infection as a direct cause of neuralgic amyotrophy.
Journal
Muscle & nerve
Author(s)
Silva M., Wicki B., Tsouni P., Cunningham S., Doerig C., Zanetti G., Aubert V., Sahli R., Moradpour D., Kuntzer T.
ISSN
1097-4598 (Electronic)
ISSN-L
0148-639X
Publication state
Published
Issued date
08/2016
Peer-reviewed
Oui
Volume
54
Number
2
Pages
325-327
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
We describe a patient who developed neuralgic amyotrophy (NA) related to hepatitis E virus (HEV) infection.
The patient underwent neurological and electrodiagnostic examinations, high-resolution analysis of serological changes, and HEV load profile, and was treated with intravenous immunoglobulin.
There was evidence of bilateral, asymmetric acute inflammatory cervical polyradiculopathy and possible brachial plexopathy. Positive serum anti-HEV IgM was followed by seroconversion to anti-HEV IgG positivity. A calculated anti-HEV antibody index was compatible with intrathecal synthesis, and HEV genotype 3 RNA was found in serum and cerebrospinal fluid (CSF). Liver function tests returned to normal within 6 weeks.
Bilateral involvement of cervical nerve roots and/or plexus, elevated liver function tests, and abnormal CSF are typical features of HEV-associated NA. The pathogenesis involves possible immune-mediated mechanisms. However, our findings support the hypothesis that HEV-related NA is associated with direct infection. Muscle Nerve 54: 325-327, 2016.

Keywords
Brachial Plexus Neuritis/etiology, Brachial Plexus Neuritis/physiopathology, Brachial Plexus Neuritis/virology, Hepatitis E/complications, Hepatitis E virus/pathogenicity, Humans, Male, HEV RNA, acute cervical radiculoplexopathy, anti-HEV antibody, intravenous immunoglobulins, neuralgic amyotrophy
Pubmed
Web of science
Create date
10/03/2016 19:33
Last modification date
20/08/2019 14:11
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