Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Mattsson, N.; Groot, C.; Jansen, W.J.; Landau, S.M.; Villemagne, V.L.; Engelborghs, S.; Mintun, M.M.; Lleo, A.; Molinuevo, J.L.; Jagust, W.J.; Frisoni, G.B.; Ivanoiu, A.; Chételat, G.; Resende de Oliveira, C.; Rodrigue, K.M.; Kornhuber, J.; Wallin, A.; Klimkowicz-Mrowiec, A.; Kandimalla, R.; Popp, J.; Aalten, P.P.; Aarsland, D.; Alcolea, D.; Almdahl, I.S.; Baldeiras, I.; van Buchem, M.A.; Cavedo, E.; Chen, K.; Cohen, A.D.; Förster, S.; Fortea, J.; Frederiksen, K.S.; Freund-Levi, Y.; Gill, K.D.; Gkatzima, O.; Grimmer, T.; Hampel, H.; Herukka, S.K.; Johannsen, P.; van Laere, K.; de Leon, M.J.; Maier, W.; Marcusson, J.; Meulenbroek, O.; Møllergård, H.M.; Morris, J.C.; Mroczko, B.; Nordlund, A.; Prabhakar, S.; Peters, O.; Rami, L.; Rodríguez-Rodríguez, E.; Roe, C.M.; Rüther, E.; Santana, I.; Schröder, J.; Seo, S.W.; Soininen, H.; Spiru, L.; Stomrud, E.; Struyfs, H.; Teunissen, C.E.; Verhey, FRJ; Vos, SJB; van Waalwijk van Doorn, LJC; Waldemar, G.; Wallin, Å.K.; Wiltfang, J.; Vandenberghe, R.; Brooks, D.J.; Fladby, T.; Rowe, C.C.; Drzezga, A.; Verbeek, M.M.; Sarazin, M.; Wolk, D.A.; Fleisher, A.S.; Klunk, W.E.; Na, D.L.; Sánchez-Juan, P.; Lee, D.Y.; Nordberg, A.; Tsolaki, M.; Camus, V.; Rinne, J.O.; Fagan, A.M.; Zetterberg, H.; Blennow, K.; Rabinovici, G.D.; Hansson, O.; van Berckel, BNM; van der Flier, W.M.; Scheltens, P.; Visser, P.J.; Ossenkoppele, R.

doi:10.1016/j.jalz.2018.02.009

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

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Serval ID

serval:BIB_2BF0DD8008FD

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Journal

Alzheimer's & dementia

Author(s)

Mattsson N., Groot C., Jansen W.J., Landau S.M., Villemagne V.L., Engelborghs S., Mintun M.M., Lleo A., Molinuevo J.L., Jagust W.J., Frisoni G.B., Ivanoiu A., Chételat G., Resende de Oliveira C., Rodrigue K.M., Kornhuber J., Wallin A., Klimkowicz-Mrowiec A., Kandimalla R., Popp J., Aalten P.P., Aarsland D., Alcolea D., Almdahl I.S., Baldeiras I., van Buchem M.A., Cavedo E., Chen K., Cohen A.D., Förster S., Fortea J., Frederiksen K.S., Freund-Levi Y., Gill K.D., Gkatzima O., Grimmer T., Hampel H., Herukka S.K., Johannsen P., van Laere K., de Leon M.J., Maier W., Marcusson J., Meulenbroek O., Møllergård H.M., Morris J.C., Mroczko B., Nordlund A., Prabhakar S., Peters O., Rami L., Rodríguez-Rodríguez E., Roe C.M., Rüther E., Santana I., Schröder J., Seo S.W., Soininen H., Spiru L., Stomrud E., Struyfs H., Teunissen C.E., Verhey FRJ, Vos SJB, van Waalwijk van Doorn LJC, Waldemar G., Wallin Å.K., Wiltfang J., Vandenberghe R., Brooks D.J., Fladby T., Rowe C.C., Drzezga A., Verbeek M.M., Sarazin M., Wolk D.A., Fleisher A.S., Klunk W.E., Na D.L., Sánchez-Juan P., Lee D.Y., Nordberg A., Tsolaki M., Camus V., Rinne J.O., Fagan A.M., Zetterberg H., Blennow K., Rabinovici G.D., Hansson O., van Berckel BNM, van der Flier W.M., Scheltens P., Visser P.J., Ossenkoppele R.

ISSN

1552-5279 (Electronic)

ISSN-L

1552-5260

Publication state

Published

Issued date

07/2018

Peer-reviewed

Oui

Volume

Number

Pages

913-924

Language

english

Notes

Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Abstract

Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology.
We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location.
The APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in Aβ+ cognitively normal and Aβ+ mild cognitive impairment (P < .05) but not in Aβ+ AD dementia (P = .66). The prevalence was highest in Northern Europe but did not vary by sex or education.
The APOE ε4 prevalence in AD was higher than that in previous studies, which did not require presence of Aβ pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.

Keywords

Aged, Alleles, Alzheimer Disease/metabolism, Amyloid beta-Peptides/metabolism, Apolipoprotein E4/genetics, Biomarkers/cerebrospinal fluid, Cognitive Dysfunction/metabolism, Europe, Female, Humans, Male, Positron-Emission Tomography, Prevalence, APOE, Age, Alzheimer's disease, Amyloid, CSF, Education, Geographical location, Mild cognitive impairment, PET, Sex, Subjective cognitive decline

OAI-PMH

oai:serval.unil.ch:BIB_2BF0DD8008FD

DOI

10.1016/j.jalz.2018.02.009

Pubmed

29601787

Web of science

000438783200009

Create date

03/04/2018 13:07

Last modification date

20/08/2019 13:11

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Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

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