Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.

Details

Serval ID
serval:BIB_2BEDD47445C8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.
Journal
Seminars in immunology
Author(s)
Pot C., Apetoh L., Awasthi A., Kuchroo V.K.
ISSN
1096-3618 (Electronic)
ISSN-L
1044-5323
Publication state
Published
Issued date
12/2011
Peer-reviewed
Oui
Volume
23
Number
6
Pages
438-445
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines, alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced activation of signal transducer and activator of transcription (Stat)1 and Stat3 promotes the generation of IL-10- producing type 1 regulatory T (Tr1) cells that inhibit effector T cells. In addition, IL-27 also suppresses the development of pathogenic IL-17-producing CD4(+) T cells (T(H)17) cells suggesting that pharmacological manipulations of IL-27 signaling pathway could be exploited therapeutically in regulating tissue inflammation. Here, we review how IL-27 controls inflammation through the regulation of Tr1 and T(H)17 responses.
Keywords
Animals, Autoimmune Diseases/immunology, Humans, Interleukin-10/biosynthesis, Interleukin-10/immunology, Interleukins/immunology, T-Lymphocytes, Regulatory/immunology, Th17 Cells/immunology
Pubmed
Web of science
Create date
21/08/2018 16:06
Last modification date
20/08/2019 13:11
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