Pathologies épithéliales cornéennes et insuffisance en cellules souches limbiques [Corneal epithelial diseases related to limbal stem cell deficiency]

Details

Serval ID
serval:BIB_2BDE73B894BE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Pathologies épithéliales cornéennes et insuffisance en cellules souches limbiques [Corneal epithelial diseases related to limbal stem cell deficiency]
Journal
Journal Français d'Ophtalmologie
Author(s)
Majo F., Barrandon Y., Othenin-Girard P., Toublanc M., Hoang-Xuan T.
ISSN
1773-0597
Publication state
Published
Issued date
11/2006
Peer-reviewed
Oui
Volume
29
Number
9
Pages
1060-1069
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review
Abstract
Treatment of corneal epithelial diseases induced by limbal stem cell deficiency is an important challenge in ocular surface reconstruction. Since the 1990s, corneal stem cells have been localized in the limbus. This new concept completely changed the way we consider ocular surface reconstruction, with new diseases now found to be isolated in the ocular surface. Limbus insufficiency syndromes are specific depending on their origin (congenital or acquired), their expression (unilateral or bilateral, partial or total), their progression (acute or chronic), and the mechanism involved (burn, infection, chronic inflammation, etc.). Some of these diseases are local diseases and others are systemic diseases. Clinically, limbus insufficiency is a switch of the normal corneal epithelial phenotype (expression of a specific keratin, avascularity, and transparency of the corneal matrix) in an opaque and fibrovascularized cornea. In terms of cellular biology, a phenotype is a terminal expression of a cell differentiation process. This process is the outcome of the interaction between the genome of a cell or a group of cells with their microenvironment. In limbus insufficiency, epithelial cells and corneal matrix are destroyed, and it is the destruction of these two components that leads to limbus insufficiency syndrome.
Keywords
Cell Differentiation, Corneal Diseases, Epithelium, Corneal, Humans, Limbus Corneae, Stem Cells
Pubmed
Web of science
Create date
28/01/2008 8:41
Last modification date
20/08/2019 13:11
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