Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.

Details

Serval ID
serval:BIB_2BB6B14A8E2A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.
Journal
Journal of the American College of Cardiology
Author(s)
Assimes T.L., Hólm H., Kathiresan S., Reilly M.P., Thorleifsson G., Voight B.F., Erdmann J., Willenborg C., Vaidya D., Xie C., Patterson C.C., Morgan T.M., Burnett M.S., Li M., Hlatky M.A., Knowles J.W., Thompson J.R., Absher D., Iribarren C., Go A., Fortmann S.P., Sidney S., Risch N., Tang H., Myers R.M., Berger K., Stoll M., Shah S.H., Thorgeirsson G., Andersen K., Havulinna A.S., Herrera J.E., Faraday N., Kim Y., Kral B.G., Mathias R.A., Ruczinski I., Suktitipat B., Wilson A.F., Yanek L.R., Becker L.C., Linsel-Nitschke P., Lieb W., König I.R., Hengstenberg C., Fischer M., Stark K., Reinhard W., Winogradow J., Grassl M., Grosshennig A., Preuss M., Schreiber S., Wichmann H.E., Meisinger C., Yee J., Friedlander Y., Do R., Meigs J.B., Williams G., Nathan D.M., MacRae C.A., Qu L., Wilensky R.L., Matthai W.H., Qasim A.N., Hakonarson H., Pichard A.D., Kent K.M., Satler L., Lindsay J.M., Waksman R., Knouff C.W., Waterworth D.M., Walker M.C., Mooser V.E., Marrugat J., Lucas G., Subirana I., Sala J., Ramos R., Martinelli N., Olivieri O., Trabetti E., Malerba G., Pignatti P.F., Guiducci C., Mirel D., Parkin M., Hirschhorn J.N., Asselta R., Duga S., Musunuru K., Daly M.J., Purcell S., Eifert S., Braund P.S., Wright B.J., Balmforth A.J., Ball S.G., Cardiogenics , Ouwehand W.H., Ouwehand W.H., Deloukas P., Scholz M., Cambien F., Huge A., Scheffold T., Salomaa V., Girelli D., Granger C.B., Peltonen L., McKeown P.P., Altshuler D., Melander O., Devaney J.M., Epstein S.E., Rader D.J., Elosua R., Engert J.C., Anand S.S., Hall A.S., Ziegler A., O'Donnell C.J., Spertus J.A., Siscovick D., Schwartz S.M., Becker D., Thorsteinsdottir U., Stefansson K., Schunkert H., Samani N.J., Quertermous T.
Working group(s)
Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium
Contributor(s)
Cardiogenics 
ISSN
1558-3597 (Electronic)
ISSN-L
0735-1097
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
56
Number
19
Pages
1552-1563
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Abstract
OBJECTIVES: We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD).
BACKGROUND: Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers.
METHODS: The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports.
RESULTS: A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of ≥2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups.
CONCLUSIONS: The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study.
Keywords
Arginine/genetics, Case-Control Studies, Coronary Artery Disease/enzymology, Coronary Artery Disease/epidemiology, Female, Genome-Wide Association Study/methods, Humans, Internationality, Kinesin/genetics, Male, Middle Aged, Polymorphism, Single Nucleotide/genetics, Risk Factors, Tryptophan/genetics
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2013 10:56
Last modification date
20/08/2019 13:11
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