JNK3 Is Required for the Cytoprotective Effect of Exendin 4.

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State: Public
Version: Final published version
Serval ID
serval:BIB_2BA4EFC99753
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
JNK3 Is Required for the Cytoprotective Effect of Exendin 4.
Journal
Journal of Diabetes Research
Author(s)
Ezanno H., Pawlowski V., Abdelli S., Boutry R., Gmyr V., Kerr-Conte J., Bonny C., Pattou F., Abderrahmani A.
ISSN
2314-6753 (Electronic)
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
2014
Pages
814854
Language
english
Abstract
Preservation of beta cell against apoptosis is one of the therapeutic benefits of the glucagon-like peptide-1 (GLP1) antidiabetic mimetics for preserving the functional beta cell mass exposed to diabetogenic condition including proinflammatory cytokines. The mitogen activated protein kinase 10 also called c-jun amino-terminal kinase 3 (JNK3) plays a protective role in insulin-secreting cells against death caused by cytokines. In this study, we investigated whether the JNK3 expression is associated with the protective effect elicited by the GLP1 mimetic exendin 4. We found an increase in the abundance of JNK3 in isolated human islets and INS-1E cells cultured with exendin 4. Induction of JNK3 by exendin 4 was associated with an increased survival of INS-1E cells. Silencing of JNK3 prevented the cytoprotective effect of exendin 4 against apoptosis elicited by culture condition and cytokines. These results emphasize the requirement of JNK3 in the antiapoptotic effects of exendin 4.
Pubmed
Web of science
Open Access
Yes
Create date
27/07/2014 15:20
Last modification date
20/08/2019 13:11
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