High prevalence of advanced fibrosis in association with the metabolic syndrome in a Belgian prospective cohort of NAFLD patients with elevated ALT. Results of the Belgian NAFLD registry.

Details

Serval ID
serval:BIB_2B89D1E7E87C
Type
Article: article from journal or magazin.
Collection
Publications
Title
High prevalence of advanced fibrosis in association with the metabolic syndrome in a Belgian prospective cohort of NAFLD patients with elevated ALT. Results of the Belgian NAFLD registry.
Journal
Acta Gastro-enterologica Belgica
Author(s)
Francque S., De Maeght S., Adler M., Deltenre P., de Galocsy C., Orlent H., Van Steenbergen W., Bastens B., Wain E., Langlet P., Lasser L., Verlinden W., Van Marck E., Henrion J.
Working group(s)
Steering Committee of the Belgian Association for the Study of the Liver
ISSN
0001-5644 (Print)
ISSN-L
0001-5644
Publication state
Published
Issued date
2011
Volume
74
Number
1
Pages
9-16
Language
english
Notes
Publication types: Journal Article ; Multicenter StudyPublication Status: ppublish
Abstract
INTRODUCTION: Non-alcoholic Fatty Liver Disease (NAFLD) is increasingly recognised as a source of liver related morbidity and mortality. Hard data on epidemiology and natural history are scarce.
AIM: To study demographic and metabolic characteristics of the NAFLD patients seen by Belgian hepatologists.
METHODS: Belgian hepatologists filled in a questionnaire for every newly diagnosed NAFLD patient between January 1st and December 31st 2004. Liver biopsy was advised if ALT > 1.5 x ULN and if 3/5 of the criteria for the metabolic syndrome (MS) (ATPI-II) were present, but was not mandatory. Biopsy was scored using the Brunt classification.
RESULTS: 230 patients were prospectively included in 9 centres; 54% were males; mean age was 49.4 +/- 13.9 y; mean BMI was 30.6 +/- 4.6 kg/m2. The MS was present in 53%. In 16% formerly undiagnosed diabetes was discovered. 51% had a liver biopsy: 25% met the criteria, 26% did not. Grading did not differ between patients with or without MS. Staging was significantly more severe in patients with MS (2.43 +/- 1.25 vs. 1.73 +/- 1.18, p < 0.001). A subgroup of patients with GGT > 5 x ULN were significantly older (55.9 vs. 47.64 y, p = 0.02), more frequently diabetic (53% vs. 23%, p = 0.01) and had more advanced fibrosis (3.42 vs. 1.08, p = 0.008). ALT levels were variable.
CONCLUSIONS: The MS is highly prevalent in Belgian NAFLD patients and is associated with more severe disease. Mild to moderate fibrosis is frequent, and the proposed criteria for liver biopsy are not accurate in selecting these patients. Patients with elevated GGT constitute a subgroup with more advanced disease.
Keywords
Adolescent, Adult, Aged, Alanine Transaminase/blood, Belgium/epidemiology, Cohort Studies, Fatty Liver/epidemiology, Fatty Liver/metabolism, Female, Humans, Liver Cirrhosis/epidemiology, Liver Cirrhosis/metabolism, Male, Metabolic Syndrome X/epidemiology, Metabolic Syndrome X/metabolism, Middle Aged, Prevalence, Registries/statistics & numerical data, Young Adult
Pubmed
Web of science
Create date
06/12/2013 10:09
Last modification date
20/08/2019 13:10
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