Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.

Details

Serval ID
serval:BIB_2B6BCE4AC3FB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.
Journal
Molecular Psychiatry
Author(s)
Berrettini W., Yuan X., Tozzi F., Song K., Francks C., Chilcoat H., Waterworth D., Muglia P., Mooser V.
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
13
Number
4
Pages
368-373
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Abstract
Twin studies indicate that additive genetic effects explain most of the variance in nicotine dependence (ND), a construct emphasizing habitual heavy smoking despite adverse consequences, tolerance and withdrawal. To detect ND alleles, we assessed cigarettes per day (CPD) regularly smoked, in two European populations via whole genome association techniques. In these approximately 7500 persons, a common haplotype in the CHRNA3-CHRNA5 nicotinic receptor subunit gene cluster was associated with CPD (nominal P=6.9 x 10(-5)). In a third set of European populations (n= approximately 7500) which had been genotyped for approximately 6000 SNPs in approximately 2000 genes, an allele in the same haplotype was associated with CPD (nominal P=2.6 x 10(-6)). These results (in three independent populations of European origin, totaling approximately 15 000 individuals) suggest that a common haplotype in the CHRNA5/CHRNA3 gene cluster on chromosome 15 contains alleles, which predispose to ND.
Keywords
Adult, Aged, Alleles, Case-Control Studies, Chromosomes, Human, Pair 15/genetics, Female, Genetic Predisposition to Disease, Genotype, Humans, Linkage Disequilibrium, Male, Microarray Analysis/methods, Middle Aged, Nerve Tissue Proteins/genetics, Polymorphism, Single Nucleotide/genetics, Receptors, Nicotinic/genetics, Retrospective Studies, Sensitivity and Specificity, Tobacco Use Disorder/epidemiology, Tobacco Use Disorder/genetics
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2013 10:56
Last modification date
20/08/2019 13:10
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