European collaborative study of early-onset bipolar disorder: Evidence for genetic heterogeneity on 2q14 according to age at onset.

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State: Public
Version: author
Serval ID
serval:BIB_2B591FB3EAB6
Type
Article: article from journal or magazin.
Collection
Publications
Title
European collaborative study of early-onset bipolar disorder: Evidence for genetic heterogeneity on 2q14 according to age at onset.
Journal
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Author(s)
Mathieu F., Dizier M.H., Etain B., Jamain S., Rietschel M., Maier W., Albus M., McKeon P., Roche S., Blackwood D., Muir W.J., Henry C., Malafosse A., Preisig M., Ferrero F., Cichon S., Schumacher J., Ohlraun S., Propping P., Abou Jamra R., Schulze T.G., Zelenica D., Charon C., Marusic A., Dernovsek M.C., Gurling H., Nöthen M., Lathrop M., Leboyer M., Bellivier F.
ISSN
1552-485X[electronic], 1552-4841[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
153B
Number
8
Pages
1425-1433
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Bipolar disorder has a genetic component, but the mode of inheritance remains unclear. A previous genome scan conducted in 70 European families led to detect eight regions linked to bipolar disease. Here, we present an investigation of whether the phenotypic heterogeneity of the disorder corresponds to genetic heterogeneity in these regions using additional markers and an extended sample of families. The MLS statistic was used for linkage analyses. The predivided sample test and the maximum likelihood binomial methods were used to test genetic homogeneity between early-onset bipolar type I (cut-off of 22 years) and other types of the disorder (later onset of bipolar type I and early-onset bipolar type II), using a total of 138 independent bipolar-affected sib-pairs. Analysis of the extended sample of families supports linkage in four regions (2q14, 3p14, 16p23, and 20p12) of the eight regions of linkage suggested by our previous genome scan. Heterogeneity testing revealed genetic heterogeneity between early and late-onset bipolar type I in the 2q14 region (P = 0.0001). Only the early form of the bipolar disorder but not the late form appeared to be linked to this region. This region may therefore include a genetic factor either specifically involved in the early-onset bipolar type I or only influencing the age at onset (AAO). Our findings illustrate that stratification according to AAO may be valuable for the identification of genetic vulnerability polymorphisms.
Pubmed
Web of science
Create date
03/12/2010 12:05
Last modification date
20/08/2019 14:10
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