Makulare Drusen. Veranderungen des retinalen Pigmentepithels und angiographische Charakteristika als prognostische Merkmale. [Macular drusen. Changes in the retinal pigment epithelium and angiographic characteristics as prognostic markers]

Details

Serval ID
serval:BIB_2B565579E6DA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Makulare Drusen. Veranderungen des retinalen Pigmentepithels und angiographische Charakteristika als prognostische Merkmale. [Macular drusen. Changes in the retinal pigment epithelium and angiographic characteristics as prognostic markers]
Journal
Ophthalmologe
Author(s)
Holz  F. G., Wolfensberger  T. J., Piguet  B., Minassian  D., Bird  A. C.
ISSN
0941-293X (Print)
Publication state
Published
Issued date
12/1994
Volume
91
Number
6
Pages
735-40
Notes
English Abstract
Journal Article --- Old month value: Dec
Abstract
Drusen in the macular area may precede other manifestations of age-related macular disease associated with severe visual loss. To identify fundus changes that might be predictive of advanced age-related maculopathy, we examined 79 patients with drusen for up to 3 years. Fundus photographs and fluorescein angiograms were independently analysed by two readers in a masked fashion using a standardized grading scheme. Fourteen patients (17.7%) developed a new exudative or nonexudative lesion involving the fovea. Delayed choroidal perfusion on the fluorescein angiogram, interpreted as an indicator for diffuse thickening of Bruch's membrane and relative atrophy of the choriocapillaris, was observed in 12 patients, 5 of whom developed geographic atrophy of the retinal pigment epithelium during follow-up (P < 0.009). Additional predictive characteristics included focal hyperpigmentations (P < 0.005) and focal extrafoveal areas of atrophy of the retinal pigment epithelium within 1600 microns of the center of the fovea (P < 0.031). These ocular features allow identification of patients with macular drusen at high risk for the development of complicating macular lesions.
Keywords
Aged Atrophy Bruch Membrane/pathology Choroid/pathology Female *Fluorescein Angiography Humans Macular Degeneration/*diagnosis/pathology Male Pigment Epithelium of Eye/*pathology Prognosis Retinal Drusen/*diagnosis/pathology Vision, Low/diagnosis/pathology
Pubmed
Create date
28/01/2008 13:05
Last modification date
20/08/2019 13:10
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