Current concepts of management in radiotherapy for head and neck squamous-cell cancer.

Details

Serval ID
serval:BIB_2B516D15FE9F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Current concepts of management in radiotherapy for head and neck squamous-cell cancer.
Journal
Oral Oncology
Author(s)
Mazeron R., Tao Y., Lusinchi A., Bourhis J.
ISSN
1879-0593 (Electronic)
ISSN-L
1368-8375
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
45
Number
4-5
Pages
402-408
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Radiotherapy plays a key role in the management of early stage and locally advanced head and neck squamous-cell carcinomas (HNSCC) either alone or, more frequently combined with surgery and/or chemotherapy. Several approaches have been developed to improve its efficacy while maintaining acceptable toxicities, such as altered fractionated radiotherapy or concomitant chemoradiotherapy which have both improved the anti-tumor efficacy of radiotherapy. Of particular interest is concomitant chemoradiotherapy (CT-RT) which is the most commonly used approach in locally advanced disease. Taxanes and platinum-based induction chemotherapy could constitute an option in the treatment of locally advanced HNSCC and it's contribution before concomitant RT-CT is currently under investigation. More recently, epidermal growth factor receptor (EGFr) molecular targeting with cetuximab combined with radiotherapy has been successfully tested in a large randomized trial and this combination constitutes a new option, especially for patients with medical co-morbidities. Finally management of treatment related acute or late toxicity remains an important issue and in the last decade major achievements have been obtained in this field especially using intensity modulated radiotherapy (IMRT).
Keywords
Antibodies, Monoclonal/therapeutic use, Antibodies, Monoclonal, Humanized, Antineoplastic Agents/therapeutic use, Carcinoma, Squamous Cell/drug therapy, Carcinoma, Squamous Cell/radiotherapy, Cell Hypoxia, Chemotherapy, Adjuvant/methods, Combined Modality Therapy/methods, Head and Neck Neoplasms/drug therapy, Head and Neck Neoplasms/radiotherapy, Humans, Platinum Compounds/therapeutic use, Radiotherapy, Adjuvant/methods, Taxoids/therapeutic use, Treatment Outcome
Pubmed
Create date
01/12/2014 17:20
Last modification date
20/08/2019 13:10
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