Discrepancy between antihypertensive effect and angiotensin converting enzyme inhibition by captopril

Details

Serval ID
serval:BIB_2B37F3472905
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Discrepancy between antihypertensive effect and angiotensin converting enzyme inhibition by captopril
Journal
Hypertension
Author(s)
Waeber B., Brunner  H. R., Brunner  D. B., Curtet  A. L., Turini  G. A., Gavras H.
ISSN
0194-911X
Publication state
Published
Issued date
1980
Peer-reviewed
Oui
Volume
2
Number
2
Pages
236-42
Language
english
Notes
Journal Article
Abstract
Captopril, an inhibitor of angiotensin converting enzyme, was administered twice daily to 13 hypertensive patients for a mean period of 9 weeks. Continuous blood pressure control in the ambulatory patients was established with a portable blood pressure recorder. Notwithstanding, in eight patients with normal renal function, plasma converting enzyme was found to resume normal activity before administration of the morning dose of captopril. Only in 5 patients with impaired renal function did some blockade of plasma converting enzyme persist for more than 12 hours. Measured plasma converting enzyme activity seemed to reflect total conversion of angiotensin I, including conversion in the pulmonary vascular bed, since changes in its activity were closely paralled by changes in plasma aldosterone levels. Bradykinin accumulation seems unlikely when converting enzyme and thus, presumably, kininase II has resumed normal activity. Captopril administration does not seem to alter plasma epinephrine or norepinephrine levels. Blood pressure reduction in the face of normal angiotensin converting enzyme activity is probably due to hyporesponsiveness of the arterioles to pressor hormones, which may be due to specific renin-related and/or nonspecific effects of captopril.
Keywords
AdultAldosterone/*bloodBlood Pressure/drug effectsCaptopril/*pharmacology/therapeutic useFemaleHumansHypertension/drug therapyMaleMiddle AgedPeptidyl-Dipeptidase A/*bloodProline/*analogs & derivativesRenin/*blood
Pubmed
Web of science
Create date
04/03/2009 15:05
Last modification date
20/08/2019 13:10
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