Resection with primary anastomosis vs nonrestorative resection for perforated diverticulitis with peritonitis: a systematic review and meta-analysis.

Details

Serval ID
serval:BIB_2B24141E9BC4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Resection with primary anastomosis vs nonrestorative resection for perforated diverticulitis with peritonitis: a systematic review and meta-analysis.
Journal
Colorectal disease
Author(s)
Gachabayov M., Oberkofler C.E., Tuech J.J., Hahnloser D., Bergamaschi R.
ISSN
1463-1318 (Electronic)
ISSN-L
1462-8910
Publication state
Published
Issued date
09/2018
Peer-reviewed
Oui
Volume
20
Number
9
Pages
753-770
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Meta-Analysis ; Systematic Review
Publication Status: ppublish
Abstract
It is still controversial whether the optimal operation for perforated diverticulitis with peritonitis is primary anastomosis (PRA) or nonrestorative resection (NRR). The aim of this systematic review and meta-analysis was to evaluate mortality and morbidity rates following emergency resection for perforated diverticulitis with peritonitis and ostomy reversal, as well as ostomy nonreversal rates.
The Pubmed, EMBASE, Cochrane Library, MEDLINE via Ovid, CINAHL and Web of Science databases were systematically searched. Mortality was the primary end-point. A subgroup meta-analysis of randomized controlled trials was performed in addition to a meta-analysis of all eligible studies. Odds ratios (ORs) and mean difference (MD) were calculated for dichotomous and continuous outcomes, respectively.
Seventeen studies, including three randomized controlled trials (RCTs), involving 1016 patients (392 PRA vs 624 NRR) were included. Overall, mortality was significantly lower in patients with PRA compared with patients with NRR [OR (95% CI) = 0.38 (0.24, 0.60), P < 0.0001]. Organ/space surgical site infection (SSI) [OR (95% CI) = 0.25 (0.10, 0.63), P = 0.003], reoperation [OR (95% CI) = 0.48 (0.25, 0.91), P = 0.02] and ostomy nonreversal rates [OR (95% CI) = 0.27 (0.09, 0.84), P = 0.02] were significantly decreased in PRA. In the RCTs, the mortality rate did not differ [OR (95% CI) = 0.46 (0.15, 1.38), P = 0.17]. The mean operating time for PRA was significantly longer than for NRR [MD (95% CI) = 19.96 (7.40, 32.52), P = 0.002]. Organ/space SSI [OR (95% CI) = 0.28 (0.09, 0.82), P = 0.02] was lower after PRA. Ostomy nonreversal rates were lower after PRA. The difference was not statistically significant [OR (95% CI) = 0.26 (0.06, 1.11), P = 0.07]. However, it was clinically significant [number needed to treat/harm (95% CI) = 5 (3.1, 8.9)].
This meta-analysis found that organ/space SSI rates as well as ostomy nonreversal rates were decreased in PRA at the cost of prolonging the operating time.
Keywords
Anastomosis, Surgical/adverse effects, Anastomosis, Surgical/methods, Colectomy/adverse effects, Colectomy/methods, Colostomy/adverse effects, Colostomy/methods, Comorbidity, Diverticulitis, Colonic/diagnosis, Diverticulitis, Colonic/epidemiology, Diverticulitis, Colonic/surgery, Female, Humans, Intestinal Perforation/diagnosis, Intestinal Perforation/epidemiology, Intestinal Perforation/surgery, Male, Operative Time, Peritonitis/diagnosis, Peritonitis/epidemiology, Peritonitis/surgery, Postoperative Complications/mortality, Postoperative Complications/physiopathology, Prognosis, Randomized Controlled Trials as Topic, Risk Assessment, Survival Analysis, Treatment Outcome, Hartmann's procedure, Perforated diverticulitis, meta-analysis, peritonitis, primary anastomosis
Pubmed
Web of science
Open Access
Yes
Create date
26/04/2018 16:34
Last modification date
22/10/2019 5:11
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