Gender differences in HIV progression to AIDS and death in industrialized countries: slower disease progression following HIV seroconversion in women.

Details

Serval ID
serval:BIB_2AFAD18512A0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gender differences in HIV progression to AIDS and death in industrialized countries: slower disease progression following HIV seroconversion in women.
Journal
American Journal of Epidemiology
Author(s)
Jarrin I., Geskus R., Bhaskaran K., Prins M., Perez-Hoyos S., Muga R., Hernández-Aguado I., Meyer L., Porter K., del Amo J.
Working group(s)
CASCADE Collaboration
Contributor(s)
del Amo J., Meyer L., Bucher H., Chêne G., Pillay D., Prins M., Rosinska M., Sabin C., Touloumi G., Porter K., Bhaskaran K., Walker S., Babiker A., Darbyshire J., Bucher H., de Luca A., Fisher M., Goujard C., Muga R., Kaldor J., Kelleher T., Gelgor L., Ramacciotti T., Cooper D., Smith D., Gill J., Jørgensen LB., Nielsen C., Pedersen C., Lutsar I., Chêne G., Dabis F., Thiebaut R., Masquelier B., Costagliola D., Vanhems P., Meyer L., Boufassa F., Hamouda O., Kucherer C., Touloumi G., Pantazis N., Hatzakis A., Paraskevis D., Karafoulidou A., Rezza G., Dorrucci M., Longo B., Balotta C., Prins M., van Asten L., van der Bij A., Geskus R., Coutinho R., Sannes M., Brubakk O., Eskild A., Bruun JN., Rosinska M., Camacho R., Smolskaya T., Muga R., Tor J., de Olalla PG. , Caylà J., del Amo J., del Romero J., Pérez-Hoyos S., Aguado IH., Belda J., Bucher H., Rickenbach M., Francioli P., Malyuta R., Brettle R., Delpech V., Lattimore S., Murphy G., Parry J., Gill N., Sabin C., Lee C., Porter K., Johnson A., Phillips A., Babiker A., Darbyshire J., Delpech V., Pillay D., Jaffe H.
ISSN
1476-6256 (Electronic)
ISSN-L
0002-9262
Publication state
Published
Issued date
09/2008
Peer-reviewed
Oui
Volume
168
Number
5
Pages
532-540
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To evaluate sex differences in human immunodeficiency virus (HIV) disease progression before (pre-1997) and after (1997-2006) introduction of highly active antiretroviral therapy, the authors used data from a collaboration of 23 HIV seroconverter cohort studies from Europe, Australia, and Canada restricted to the 6,923 seroconverters infected through injecting drug use and sex between men and women. Within a competing risk framework, they used Cox proportional hazards models allowing for late entry to evaluate sex differences in time from HIV seroconversion to death, to acquired immunodeficiency syndrome (AIDS), and to each first AIDS-defining disease and death without AIDS. While no significant sex differences were found before 1997, from 1997 onward, women had a lower risk of AIDS (adjusted cumulative relative risk (aCRR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and death (adjusted hazard ratio = 0.68, 95% CI: 0.56, 0.82) than men did. Compared with men, women also had lower risks of AIDS dementia complex (aCRR = 0.23, 95% CI: 0.07, 0.74), tuberculosis (aCRR = 0.60, 95% CI: 0.39, 0.92), Kaposi's sarcoma (aCRR = 0.27, 95% CI: 0.07, 0.99), lymphomas (aCRR = 0.47, 95% CI: 0.23, 0.96), and death without AIDS (aCRR = 0.74, 95% CI: 0.56, 0.98). Sex differences in HIV disease progression have become larger and statistically significant in the era of highly active antiretroviral therapy, supporting a stronger impact of health interventions among women.
Keywords
AIDS-Related Opportunistic Infections/epidemiology, Acquired Immunodeficiency Syndrome/drug therapy, Acquired Immunodeficiency Syndrome/epidemiology, Adult, Antiretroviral Therapy, Highly Active/methods, Australia/epidemiology, Canada/epidemiology, Cohort Studies, Confidence Intervals, Developed Countries/statistics & numerical data, Europe/epidemiology, Female, HIV Infections/complications, HIV Infections/diagnosis, HIV Infections/</QualifierName> <QualifierName MajorTopicYN="N">, HIV Seropositivity, HIV-1/isolation & purification, Humans, Male, Odds Ratio, Proportional Hazards Models, Risk, Sex Factors, Substance Abuse, Intravenous/complications
Pubmed
Web of science
Open Access
Yes
Create date
06/03/2009 8:39
Last modification date
20/08/2019 13:10
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