Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.

Details

Serval ID
serval:BIB_2ADBC9AEA856
Type
Article: article from journal or magazin.
Collection
Publications
Title
Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.
Journal
Virchows Archiv
Author(s)
Pinheiro C., Longatto-Filho A., Scapulatempo C., Ferreira L., Martins S., Pellerin L., Rodrigues M., Alves V.A., Schmitt F., Baltazar F.
ISSN
0945-6317
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
452
Number
2
Pages
139-146
Language
english
Notes
Publication types: Journal Article
Abstract
Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT expression in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the expressions of MCT1, 2, and 4 in a well characterized series of CRC and assess their role in CRC carcinogenesis. CRC samples (126 cases) were analyzed for MCT1, MCT2, and MCT4 immunoexpression and findings correlated with clinico-pathological parameters. Expression of all MCT isoforms in tumour cells was significantly increased when compared to adjacent normal epithelium. Remarkably, there was a significant gain of membrane expression for MCT1 and MCT4 and loss of plasma membrane expression for MCT2 in tumour cells. Plasma membrane expression of MCT1 was directly related to the presence of vascular invasion. This is the larger study on MCT expression in CRC and evaluates for the first time its clinico-pathological significance. The increased expression of these transporters suggests an important role in CRC, which might justify their use, especially MCT1 and MCT4, as targets in CRC drug therapy.
Keywords
Adenocarcinoma, Mucinous/chemistry, Adenocarcinoma, Mucinous/metabolism, Adult, Aged, Aged, 80 and over, Cell Membrane/metabolism, Child, Preschool, Colorectal Neoplasms/chemistry, Colorectal Neoplasms/metabolism, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Monocarboxylic Acid Transporters/metabolism, Muscle Proteins/metabolism, Neoplasm Invasiveness, Neoplasm Staging, Protein Isoforms, Symporters/metabolism, Tumor Markers, Biological/metabolism
Pubmed
Web of science
Create date
31/03/2009 17:23
Last modification date
03/03/2018 15:23
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