Four cases of audio-vestibular disorders related to immunisation with SARS-CoV-2 mRNA vaccines.
Details
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_2ACA564D1A62
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Four cases of audio-vestibular disorders related to immunisation with SARS-CoV-2 mRNA vaccines.
Journal
International journal of audiology
ISSN
1708-8186 (Electronic)
ISSN-L
1499-2027
Publication state
Published
Issued date
06/2023
Peer-reviewed
Oui
Volume
62
Number
6
Pages
587-591
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
To gain medical insight into the clinical course and safety of otolaryngologic disorders following immunisation with severe acute respiratory coronavirus (SARS-CoV-2) mRNA-based vaccines.
Case description.
We report four cases of transient audio-vestibular symptoms, which occurred shortly after inoculation of two BNT162b2 (Pfizer-BioNTech <sup>®</sup> ) and mRNA-1273 (Moderna®) vaccines.
Hearing loss was unilateral in all cases and recovered at least partially: it was associated with persistent gait instability in two cases, after 1 and 7 months. Trigger mechanisms underpinning audio-vestibular impairment remain uncertain. Immune tolerance mechanisms with off-target innate activation of T-lymphocytes may be involved in vestibulocochlear nerve disorders, as for other cranial nerves involvement.
The occurrence of audio-vestibular manifestations following mRNA-based vaccines needs ENT monitoring to support their causality in such rare vaccine-related adverse events. Audio-vestibular disorders appeared of transitory nature, including hearing loss, and should not deter further efforts in large-scale vaccination campaigns against SARS-CoV-2.
Case description.
We report four cases of transient audio-vestibular symptoms, which occurred shortly after inoculation of two BNT162b2 (Pfizer-BioNTech <sup>®</sup> ) and mRNA-1273 (Moderna®) vaccines.
Hearing loss was unilateral in all cases and recovered at least partially: it was associated with persistent gait instability in two cases, after 1 and 7 months. Trigger mechanisms underpinning audio-vestibular impairment remain uncertain. Immune tolerance mechanisms with off-target innate activation of T-lymphocytes may be involved in vestibulocochlear nerve disorders, as for other cranial nerves involvement.
The occurrence of audio-vestibular manifestations following mRNA-based vaccines needs ENT monitoring to support their causality in such rare vaccine-related adverse events. Audio-vestibular disorders appeared of transitory nature, including hearing loss, and should not deter further efforts in large-scale vaccination campaigns against SARS-CoV-2.
Keywords
Humans, SARS-CoV-2/genetics, COVID-19 Vaccines/adverse effects, BNT162 Vaccine, COVID-19/prevention & control, Immunization, Vestibular Diseases/etiology, Vestibular Diseases/genetics, Deafness, RNA, Messenger, Adverse event, COVID-19 mRNA vaccines, hearing loss, immunisation, sensorineural, vestibular neuritis
Pubmed
Web of science
Open Access
Yes
Create date
17/05/2022 12:36
Last modification date
08/06/2023 5:55
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