Meta-Analysis of the Prognostic Role of Late Gadolinium Enhancement and Global Systolic Impairment in Left Ventricular Noncompaction.

Details

Serval ID
serval:BIB_2AAE5439A3DD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Meta-Analysis of the Prognostic Role of Late Gadolinium Enhancement and Global Systolic Impairment in Left Ventricular Noncompaction.
Journal
JACC. Cardiovascular imaging
Author(s)
Grigoratos C., Barison A., Ivanov A., Andreini D., Amzulescu M.S., Mazurkiewicz L., De Luca A., Grzybowski J., Masci P.G., Marczak M., Heitner J.F., Schwitter J., Gerber B.L., Emdin M., Aquaro G.D.
ISSN
1876-7591 (Electronic)
ISSN-L
1876-7591
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
12
Number
11 Pt 1
Pages
2141-2151
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The objective of this meta-analysis was to assess the predictive value of late gadolinium enhancement (LGE) and global systolic impairment for future major adverse cardiovascular events in left ventricular noncompaction (LVNC).
The prognosis of patients with LVNC, with and without left ventricular dysfunction and LGE, is still unclear.
A systematic review of published research and a meta-analysis reporting a combined endpoint of hard (cardiac death, sudden cardiac death, appropriate defibrillator firing, resuscitated cardiac arrest, cardiac transplantation, assist device implantation) and minor (heart failure hospitalization and thromboembolic events) events was performed.
Four studies with 574 patients with LVNC and 677 with no LVNC and an average follow-up duration of 5.2 years were analyzed. In patients with LVNC, LGE was associated with the combined endpoint (pooled odds ratio: 4.9; 95% confidence interval: 1.63 to 14.6; p = 0.005) and cardiac death (pooled odds ratio: 9.8; 95% confidence interval: 2.44 to 39.5; p < 0.001). Preserved left ventricular systolic function was found in 183 patients with LVNC: 25 with positive LGE and 158 with negative LGE. In LVNC with preserved ejection fraction, positive LGE was associated with hard cardiac events (odds ratio: 6.1; 95% confidence interval: 2.1 to 17.5; p < 0.001). No hard cardiac events were recorded in patients with LVNC, preserved ejection fraction, and negative LGE.
Patients with LVNC but without LGE have a better prognosis than those with LGE. When LGE is negative and global systolic function is preserved, no hard cardiac events are to be expected. Currently available criteria allow diagnosis of LVNC, but to further define the presence and prognostic significance of the disease, LGE and/or global systolic impairment must be considered for better risk stratification.
Keywords
hypertrabeculation, late gadolinium enhancement, left ventricular noncompaction, prognosis, systolic impairment
Pubmed
Web of science
Create date
10/04/2019 17:41
Last modification date
05/01/2020 7:18
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