Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study

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Serval ID
serval:BIB_2A99567A66CD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study
Journal
Clinical Infectious Diseases
Author(s)
Rauch  A., Rickenbach  M., Weber  R., Hirschel  B., Tarr  P. E., Bucher  H. C., Vernazza  P., Bernasconi  E., Zinkernagel  A. S., Evison  J., Furrer  H.
ISSN
1537-6591 (Electronic)
Publication state
Published
Issued date
08/2005
Volume
41
Number
3
Pages
395-402
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
Abstract
BACKGROUND: Data on the incidence of hepatitis C virus (HCV) infection among human immunodeficiency virus (HIV)-infected persons are sparse. It is controversial whether and how frequently HCV is transmitted by unprotected sexual intercourse. METHODS: We assessed the HCV seroprevalence and incidence of HCV infection in the Swiss HIV Cohort Study between 1988 and 2004. We investigated the association of HCV seroconversion with mode of HIV acquisition, sex, injection drug use (IDU), and constancy of condom use. Data on condom use or unsafe sexual behavior were prospectively collected between 2000 and 2004. RESULTS: The overall seroprevalence of HCV infection was 33% among a total of 7899 eligible participants and 90% among persons reporting IDU. We observed 104 HCV seroconversions among 3327 participants during a total follow-up time of 16,305 person-years, corresponding to an incidence of 0.64 cases per 100 person-years. The incidence among participants with a history of IDU was 7.4 cases per 100 person-years, compared with 0.23 cases per 100 person-years in patients without such a history (P<.001). In men who had sex with men (MSM) without a history of IDU who reported unsafe sex, the incidence was 0.7 cases per 100 person-years, compared with 0.2 cases per 100 person-years in those not reporting unsafe sex (P=.02), corresponding to an incidence rate ratio of 3.5 (95% confidence interval, 1.2-10.0). The hazard of acquiring HCV infection was elevated among younger participants who were MSM. CONCLUSIONS: HCV infection incidence in the Swiss HIV Cohort Study was mainly associated with IDU. In HIV-infected MSM, HCV infection was associated with unsafe sex.
Keywords
Adult Cohort Studies Female HIV Infections/*complications Hepatitis C/*complications/*epidemiology *Homosexuality, Male Humans Incidence Male Prevalence Proportional Hazards Models Risk Factors Switzerland/epidemiology Unsafe Sex/*statistics & numerical data
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 8:52
Last modification date
25/09/2019 6:08
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