Regulation of Local Sleep by the Thalamic Reticular Nucleus.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_2A60E1A09EA1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Regulation of Local Sleep by the Thalamic Reticular Nucleus.
Journal
Frontiers in neuroscience
Author(s)
Vantomme G., Osorio-Forero A., Lüthi A., Fernandez LMJ
ISSN
1662-4548 (Print)
ISSN-L
1662-453X
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
13
Pages
576
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
In spite of the uniform appearance of sleep as a behavior, the sleeping brain does not produce electrical activities in unison. Different types of brain rhythms arise during sleep and vary between layers, areas, or from one functional system to another. Local heterogeneity of such activities, here referred to as local sleep, overturns fundamental tenets of sleep as a globally regulated state. However, little is still known about the neuronal circuits involved and how they can generate their own specifically-tuned sleep patterns. NREM sleep patterns emerge in the brain from interplay of activity between thalamic and cortical networks. Within this fundamental circuitry, it now turns out that the thalamic reticular nucleus (TRN) acts as a key player in local sleep control. This is based on a marked heterogeneity of the TRN in terms of its cellular and synaptic architecture, which leads to a regional diversity of NREM sleep hallmarks, such as sleep spindles, delta waves and slow oscillations. This provides first evidence for a subcortical circuit as a determinant of cortical local sleep features. Here, we review novel cellular and functional insights supporting TRN heterogeneity and how these elements come together to account for local NREM sleep. We also discuss open questions arising from these studies, focusing on mechanisms of sleep regulation and the role of local sleep in brain plasticity and cognitive functions.
Keywords
sleep spindles, slow wave activity, delta waves, neural circuit, thalamocortical
Pubmed
Web of science
Open Access
Yes
Create date
20/06/2019 6:29
Last modification date
20/08/2019 13:10
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