Microbiote et maladies rénales : liaison dangereuse ? [Gut microbiota and kidney diseases : dangerous liaisons?]

Details

Serval ID
serval:BIB_2A382D8988F3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Microbiote et maladies rénales : liaison dangereuse ? [Gut microbiota and kidney diseases : dangerous liaisons?]
Journal
Revue medicale suisse
Author(s)
Ghajarzadeh-Wurzner A., Berney M., Teta D., Genton L., Pruijm M.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
21/02/2018
Peer-reviewed
Oui
Volume
14
Number
595
Pages
422-425
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Recent studies have found a relationship between the kidney and the intestinal microbiome, called the colo-renal axis. Mounting evidence suggests that patients suffering from chronic kidney disease (CKD) have an altered composition of gut microbiota. This leads to 1) the increased fermentation of intestinal proteins to uremic toxins such as p-cresyl sulphate and indoxyl sulphate, 2) an altered, more 'leaky' intestinal barrier, and 3) translocation of bacteria and toxins from the gut lumen to the circulation, inducing systemic inflammation. This may contribute to the increased morbidity and mortality in this population. Future studies are needed to confirm this hypothesis, and to assess whether manipulating the intestinal microbiota with pre-, pro-, or symbiotics may alter the development and course of CKD.
Keywords
Gastrointestinal Microbiome, Humans, Renal Insufficiency, Chronic/microbiology
Pubmed
Create date
01/03/2018 18:05
Last modification date
20/08/2019 13:09
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