Assessment of Return to Baseline Urinary and Sexual Function Following Primary Focal Cryotherapy for Nonmetastatic Prostate Cancer.

Details

Serval ID
serval:BIB_2A20DFBCC55B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Assessment of Return to Baseline Urinary and Sexual Function Following Primary Focal Cryotherapy for Nonmetastatic Prostate Cancer.
Journal
European urology focus
Author(s)
Shah T.T., Peters M., Miah S., Eldred-Evans D., Yap T., Hosking-Jervis F., Dudderidge T., Hindley R.G., McCracken S., Greene D., Nigam R., Valerio M., Winkler M., Virdi J., Arya M., Ahmed H.U., Minhas S.
ISSN
2405-4569 (Electronic)
ISSN-L
2405-4569
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
The oncological outcomes in men with clinically significant prostate cancer following focal cryotherapy are promising, although functional outcomes are under-reported.
To determine the impact of focal cryotherapy on urinary and sexual function, specifically assessing return to baseline function.
Between October 2013 and November 2016, 58 of 122 men who underwent focal cryotherapy for predominantly anterior clinically significant localised prostate cancer within a prospective registry returned patient-reported outcome measure questionnaires, which included International Prostate Symptom Score (IPSS) and International Index of Erectile Function (IIEF-15) questionnaires.
Standard cryotherapy procedure using either the SeedNet or the Visual-ICE cryotherapy system.
Primary outcome was return to baseline function of IPSS score and IIEF erectile function (EF) subdomain. Cumulative incidence and Cox-regression analyses were performed.
Probability of returning to baseline IPSS function was 78% at 12 mo and 87% at both 18 and 24 mo, with recovery seen up to 18 mo. For IIEF (EF domain), the probability of returning to baseline function was 85% at 12 mo and 89% at both 18 and 24 mo, with recovery seen up to 18 mo. Only the preoperative IIEF-EF score was associated with a poor outcome (hazard ratio 0.96, 95% confidence interval 0.93-0.999, p = 0.04). The main limitation was that only half of the patients returned their questionnaires.
In men undergoing primary focal cryotherapy, there is a high degree of preservation of urinary and erectile function with return to baseline function occurring from 3 mo and continuing up to 18 mo after focal cryotherapy.
In men who underwent focal cryotherapy for prostate cancer, approximately nine in 10 returned to their baseline urinary and sexual function. Keeping in mind that level 1 evidence and long-term data are still needed, in men who wish to preserve urinary and sexual function, focal cryotherapy may be considered an alternative treatment option to radical therapy.
Keywords
Clinically significant prostate cancer, Cryotherapy, Focal therapy, International Index of Erectile Function, International Prostate Symptom Score, Patient-reported outcome measure, Sexual function, Urinary function
Pubmed
Create date
10/10/2019 21:09
Last modification date
08/10/2020 5:27
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