Histopathology of peripapillary choroidal neovascularization.
Details
Serval ID
serval:BIB_29C92739766D
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Histopathology of peripapillary choroidal neovascularization.
Journal
Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society For Imaging In the Eye
ISSN
1938-2375 (Electronic)
ISSN-L
1542-8877
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
43 Online
Pages
e22-e26
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: epublish
Abstract
The different therapeutic responses observed among choroidal neovascularization (CNV) of different etiologies, ages, and locations might be related to the presence of varied mediators. Two surgically removed peripapillary CNVs from two different patients were analyzed. One of the patients had received one intravitreous injection of bevacizumab 3 months earlier. CNV was analyzed using conventional histology and immunohistochemistry. Histological analysis showed intense neovascularization and epithelial and glial components. Vascular endothelial growth factor (VEGF) receptors were found in the endothelial cells and the epithelial cells of the CNV. VEGF was expressed in the patient who had not been previously treated with anti-VEGF. The CNV was deeply infiltrated by glial cells and invaded by microglial cells in one case. VEGF and VEGF receptors may be expressed, suggesting that therapies aiming at VEGF may be efficient only for a subtype of CNV and at a certain time point of their evolution.
Keywords
Adult, Aged, Choroidal Neovascularization/metabolism, Choroidal Neovascularization/pathology, Humans, Immunohistochemistry, Male, Pregnancy Proteins/metabolism, Receptors, Vascular Endothelial Growth Factor/metabolism, Vascular Endothelial Growth Factors/metabolism
Pubmed
Create date
19/08/2013 15:23
Last modification date
20/08/2019 13:09