Motor conduction block and high titres of anti-GM1 ganglioside antibodies: pathological evidence of a motor neuropathy in a patient with lower motor neuron syndrome

Details

Serval ID
serval:BIB_29959DAC6193
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Motor conduction block and high titres of anti-GM1 ganglioside antibodies: pathological evidence of a motor neuropathy in a patient with lower motor neuron syndrome
Journal
Journal of Neurology, Neurosurgery and Psychiatry
Author(s)
Adams  D., Kuntzer  T., Steck  A. J., Lobrinus  A., Janzer  R. C., Regli  F.
ISSN
0022-3050 (Print)
Publication state
Published
Issued date
09/1993
Peer-reviewed
Oui
Volume
56
Number
9
Pages
982-7
Notes
Case Reports Journal Article --- Old month value: Sep
Abstract
A patient with a progressive lower motor neuron syndrome and neurophysiological evidence of motor axon loss, multifocal proximal motor nerve conduction block, and high titres of anti-ganglioside GM1 antibodies. Neuropathological findings included a predominantly proximal motor radiculoneuropathy with multifocal IgG and IgM deposits on nerve fibres associated with a loss of spinal motor neurons. These findings support an autoimmune origin of this lower motor neuron syndrome with retrograde degeneration of spinal motor neurons and severe neurogenic muscular atrophy.
Keywords
Aged Autoantibodies/blood Enzyme-Linked Immunosorbent Assay G(M1) Ganglioside/*immunology Humans Immunohistochemistry Male Motor Neuron Disease/immunology/pathology/*physiopathology Neural Conduction/physiology Neuromuscular Junction/physiopathology Peripheral Nerves/pathology Spinal Cord/pathology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 12:43
Last modification date
20/08/2019 13:09
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