Avancées recentes dans le traitement des carcinomes corticosurrénaliens [Recent advances in the treatment of adrenocortical carcinomas].

Details

Serval ID
serval:BIB_29943BAF3051
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Avancées recentes dans le traitement des carcinomes corticosurrénaliens [Recent advances in the treatment of adrenocortical carcinomas].
Journal
Revue Médicale Suisse
Author(s)
Ducry J., Berthold D., Pralong F.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2012
Volume
8
Number
362
Pages
2181-4, 2186
Language
french
Notes
Publication types: English Abstract ; Journal Article
Abstract
Adrenocortical carcinomas are rare and aggressive malignant tumors, with an incidence of 1 to 2 cases per million inhabitants. Their diagnosis is made in three clinical situations: during the work up of a syndrome of hormonal hypersecretion, during the work up of locoregional symptoms, or incidentally during an unrelated radiological procedure. Surgery is usually indicated except in situations of advanced metastatic disease. Adjuvant chemotherapy with mitotane is associated with a significant increase in disease-free survival when the drug is administered at adequate therapeutic dosage. Novel anti-mitotic therapies have recently been described for treating recurrent adrenocortical carcinoma under mitotane treatment, but their overall efficacy remains unsatisfactory.
Keywords
Adrenal Cortex Neoplasms/diagnosis, Adrenal Cortex Neoplasms/pathology, Adrenocortical Carcinoma/diagnosis, Adrenocortical Carcinoma/pathology, Antimitotic Agents/therapeutic use, Antineoplastic Agents/administration & dosage, Antineoplastic Agents/therapeutic use, Chemotherapy, Adjuvant/methods, Disease-Free Survival, Dose-Response Relationship, Drug, Humans, Incidence, Neoplasm Recurrence, Local
Pubmed
Create date
17/01/2013 8:47
Last modification date
20/08/2019 13:09
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