Effects of corticosterone on innate and humoral immune functions and oxidative stress in barn owl nestlings.

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State: Serval
Version: Final published version
Serval ID
serval:BIB_297E11A510B2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effects of corticosterone on innate and humoral immune functions and oxidative stress in barn owl nestlings.
Journal
Journal of Experimental Biology
Author(s)
Stier K.S., Almasi B., Gasparini J., Piault R., Roulin A., Jenni L.
ISSN-L
0022-0949
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
212
Number
Pt 13
Pages
2085-2091
Language
english
Abstract
The costs of coping with stressful situations are traded-off against other functions such as immune responses. This trade-off may explain why corticosterone secretion reduces immune reactions. Corticosterone differentially affects various immunity components. However, which component is suppressed varies between studies. It remains unclear whether the trade-off in energy, nutrition, autoimmunity or oxidative stress accounts for differential immunosuppression. In this study, we investigated whether corticosterone differentially affects the constitutive innate and humoral acquired immunity. We used barn owl nestlings, implanting 50% with a corticosterone-releasing pellet and the other 50% with a placebo pellet. To measure the effect on humoral immunity we vaccinated 50% of the corticosterone-nestlings and 50% of the placebo-nestlings with the antigens 'Tetravac' and the other 50% were injected with PBS. To assess the costs of elevated corticosterone, we measured body mass and resistance to oxidative stress. Administration of corticosterone increased corticosterone levels whereas vaccination induced the production of antibodies. Corticosterone reduced the production of antibodies, but it did not significantly affect the constitutive innate immunity. Corticosterone reduced body growth and resistance to oxidative stress. Under stressful conditions barn owl nestlings seem to keep the constitutive innate immunity, whereas elevated corticosterone levels negatively affected inducible immune responses. We found evidence that mounting a humoral immune reaction is not costly in terms of growth, but reduces the resistance to oxidative stress independently of corticosterone administration. We suggest that humoral immunity is suppressed because the risk of immunopathologies may be disproportionately high when mounting an antibody response under stressful situations.
Keywords
Animals, Antibody Formation/drug effects, Body Size, Corticosterone/blood, Corticosterone/pharmacology, Immunity, Innate/drug effects, Oxidative Stress, Strigiformes/growth & development, Strigiformes/immunology
Pubmed
Open Access
Yes
Create date
09/02/2009 16:56
Last modification date
08/05/2019 16:12
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