French mothers' milk deficient in DHA contains phospholipid species of potential interest for infant development.

Details

Serval ID
serval:BIB_29735479FD5E
Type
Article: article from journal or magazin.
Collection
Publications
Title
French mothers' milk deficient in DHA contains phospholipid species of potential interest for infant development.
Journal
Journal of Pediatric Gastroenterology and Nutrition
Author(s)
Garcia C., Millet V., Coste T.C., Mimoun M., Ridet A., Antona C., Simeoni U., Armand M.
ISSN
1536-4801 (Electronic)
ISSN-L
0277-2116
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
53
Number
2
Pages
206-212
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
OBJECTIVES: An insufficient human milk docosahexaenoic acid (DHA) level was reported worldwide, which leads to the question of the sufficiency of the DHA supply for infant development in the French Mediterranean area. Also, among milk lipids, phospholipids may be of high potential interest for infant brain development, being a specific vector of DHA and providing plasmalogens. We aimed to estimate the consumption of such milk compounds by preterm and term infants.
MATERIALS AND METHODS: Milk samples from 22 lactating French women living in a port city, Marseille, were collected in a neonatology department from a single full-breast expression using an electric pump. Amounts of triglycerides, total phospholipids and plasmalogens, and fatty acid profile were determined by gas chromatography, and cholesterol by enzymatic assay.
RESULTS: Depending on the infant dietary guidelines we referred to, 46% or 82% of milk samples were below the recommended DHA level (0.4% or 0.7%), and a majority exhibited high linoleic acid/α-linolenic acid and n-6/n-3 ratios, probably resulting from high linoleic acid together with low fish and seafood products consumption. DHA carried by phospholipids in a majority of specimens met the requirements for brain development for term but not for premature infants. Milk plasmalogen levels ranged from 3.4 to 39.2  mg/L.
CONCLUSIONS: Our results support the recommendation of DHA supplementation to French mothers living in a Mediterranean port city, and of decreased linoleic acid intake, to reach optimal milk composition for infant health. DHA-containing phospholipids including plasmalogen species may represent important bioactive human milk compounds.
Keywords
Animals, Child Development, Colostrum/chemistry, Dietary Fats/analysis, Docosahexaenoic Acids/analysis, Docosahexaenoic Acids/deficiency, Female, Fishes, hic" UI="D005602">France, Humans, Infant, Infant, Newborn, Infant, Premature, Male, Maternal Nutritional Physiological Phenomena, Milk, Human/chemistry, Nutritional Requirements, Nutritive Value, Phospholipids/analysis, Phospholipids/chemistry, Plasmalogens/analysis, Plasmalogens/chemistry, Premature Birth/metabolism, Reproducibility of Results, Seafood, Triglycerides/analysis, Triglycerides/chemistry
Pubmed
Web of science
Create date
22/02/2015 9:28
Last modification date
20/08/2019 13:09
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