Haematological changes from conception to childbirth: An indicator of major pregnancy complications.

Details

Serval ID
serval:BIB_296C163E9E74
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Haematological changes from conception to childbirth: An indicator of major pregnancy complications.
Journal
European journal of haematology
Author(s)
Patxot M., Stojanov M., Ojavee S.E., Gobert R.P., Kutalik Z., Gavillet M., Baud D., Robinson M.R.
ISSN
1600-0609 (Electronic)
ISSN-L
0902-4441
Publication state
Published
Issued date
08/2022
Peer-reviewed
Oui
Volume
109
Number
5
Pages
566-575
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
About 800 women die every day worldwide from pregnancy-related complications, including excessive blood loss, infections and high-blood pressure (World Health Organization, 2019). To improve screening for high-risk pregnancies, we set out to identify patterns of maternal hematological changes associated with future pregnancy complications.
Using mixed effects models, we established changes in 14 complete blood count (CBC) parameters for 1710 healthy pregnancies and compared them to measurements from 98 pregnancy-induced hypertension, 106 gestational diabetes and 339 postpartum hemorrhage cases.
Results show interindividual variations, but good individual repeatability in CBC values during physiological pregnancies, allowing the identification of specific alterations in women with obstetric complications. For example, in women with uncomplicated pregnancies, haemoglobin count decreases of 0.12 g/L (95% CI -0.16, -0.09) significantly per gestation week (p value <.001). Interestingly, this decrease is three times more pronounced in women who will develop pregnancy-induced hypertension, with an additional decrease of 0.39 g/L (95% CI -0.51, -0.26). We also confirm that obstetric complications and white CBC predict the likelihood of giving birth earlier during pregnancy.
We provide a comprehensive description of the associations between haematological changes through pregnancy and three major obstetric complications to support strategies for prevention, early-diagnosis and maternal care.
Keywords
Delivery, Obstetric/adverse effects, Female, Humans, Hypertension, Pregnancy-Induced/diagnosis, Hypertension, Pregnancy-Induced/etiology, Parturition, Postpartum Hemorrhage/diagnosis, Postpartum Hemorrhage/etiology, Pregnancy, Pregnancy Complications/etiology, clinical haematology, complete blood count, longitudinal data, maternal health, mixed effects model
Pubmed
Web of science
Open Access
Yes
Create date
13/09/2022 14:55
Last modification date
15/10/2022 5:34
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