Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials.

Details

Ressource 1Download: 10.1017-S1041610217001892.pdf (433.50 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_2962D0ECBA51
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials.
Journal
International psychogeriatrics
Author(s)
Savaskan E., Mueller H., Hoerr R., von Gunten A., Gauthier S.
ISSN
1741-203X (Electronic)
ISSN-L
1041-6102
Publication state
Published
Issued date
03/2018
Peer-reviewed
Oui
Volume
30
Number
3
Pages
285-293
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Review
Publication Status: ppublish
Abstract
ABSTRACTBackground:In randomized controlled trials, Ginkgo biloba extract EGb 761® has been found to be effective in the treatment of behavioral and psychological symptoms of dementia (BPSD).
To assess the effects of EGb 761® on specific BPSD, we analyzed data from all randomized, placebo-controlled, at least 20-week, trials of EGb 761® enrolling patients with dementia (probable Alzheimer's disease (AD), probable vascular dementia or probable AD with cerebrovascular disease) who had clinically significant BPSD (Neuropsychiatric Inventory (NPI) total score at least 6). Data were pooled and joint analyses of NPI single item composite and caregiver distress scores were performed by meta-analysis with a fixed effects model.
Four trials involving 1628 patients (EGb 761®, 814; placebo, 814) were identified; treatment duration was 22 or 24 weeks; the daily dose of EGb 761® was 240 mg in all trials. Pooled analyses including data from the full analysis sets of all trials (EGb 761®, 796 patients; placebo, 802 patients) revealed significant superiority of EGb 761® over placebo in total scores and 10 single symptom scores. Regarding caregiver distress scores, EGb 761®-treated patients improved significantly more than those receiving placebo in all symptoms except delusions, hallucinations, and elation/euphoria. The benefit of EGb 761® mainly consists of improvement in symptoms present at baseline, but the incidence of some symptoms was also decreased.
Twenty two- to twenty four-week treatment with Ginkgo biloba extract EGb 761® improved BPSD (except psychotic-like features) and caregiver distress caused by such symptoms.
Keywords
Aged, Behavioral Symptoms/complications, Behavioral Symptoms/drug therapy, Cognition/drug effects, Dementia/complications, Dementia/drug therapy, Ginkgo biloba/chemistry, Humans, Male, Mental Disorders/complications, Mental Disorders/drug therapy, Middle Aged, Phytotherapy/methods, Plant Extracts/administration & dosage, Plant Extracts/adverse effects, Plant Extracts/therapeutic use, Psychiatric Status Rating Scales, Quality of Life, Randomized Controlled Trials as Topic, Treatment Outcome, BPSD, EGb 761®, Ginkgo biloba, behavioral and psychological symptoms, dementia, meta-analysis, systematic review
Pubmed
Web of science
Open Access
Yes
Create date
03/05/2018 10:30
Last modification date
20/08/2019 13:09
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