Bone-marrow haematopoietic-stem-cell niches.

Details

Serval ID
serval:BIB_2961220A125B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Bone-marrow haematopoietic-stem-cell niches.
Journal
Nature Reviews. Immunology
Author(s)
Wilson A., Trumpp A.
ISSN
1474-1733 (Print)
ISSN-L
1474-1733
Publication state
Published
Issued date
2006
Volume
6
Number
2
Pages
93-106
Language
english
Abstract
Adult stem cells hold many promises for future clinical applications and regenerative medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so far, but in vitro expansion has been unsuccessful, limiting the future therapeutic potential of these cells. Here we review recent progress in characterizing the composition of the HSC bone-marrow microenvironment, known as the HSC niche. During homeostasis, HSCs, and therefore putative bone-marrow HSC niches, are located near bone surfaces or are associated with the sinusoidal endothelium. The molecular crosstalk between HSCs and the cellular constituents of these niches is thought to control the balance between HSC self-renewal and differentiation, indicating that future successful expansion of HSCs for therapeutic use will require three-dimensional reconstruction of a stem-cell-niche unit.
Keywords
Animals, Bone Marrow/immunology, Cell Differentiation/immunology, Hematopoietic Stem Cells/cytology, Hematopoietic Stem Cells/immunology, Homeostasis/immunology, Humans, Models, Immunological
Pubmed
Web of science
Create date
11/04/2013 13:09
Last modification date
20/08/2019 13:09
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