Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man

Details

Serval ID
serval:BIB_29409D0BA726
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man
Journal
European Journal of Gastroenterology and Hepatology
Author(s)
Felley  C. P., Corthesy-Theulaz  I., Rivero  J. L., Sipponen  P., Kaufmann  M., Bauerfeind  P., Wiesel  P. H., Brassart  D., Pfeifer  A., Blum  A. L., Michetti  P.
ISSN
0954-691X (Print)
Publication state
Published
Issued date
01/2001
Volume
13
Number
1
Pages
25-9
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
OBJECTIVE: The supernatant of Lactobacillus johnsonii La1 culture was shown to be bactericidal and to have a partial, acid-independent suppressive effect on Helicobacter pylori in humans. The aim of the present study was to investigate the effect of L. johnsonii La1-acidified milk (LC-1) on H. pylori infection. DESIGN AND METHODS: Fifty-three volunteers infected with H. pylori as determined by positive 13C-urea breath test and positive serology were randomized to receive either LC-1 or a placebo 180 ml twice a day for 3 weeks. All subjects also received clarithromycin 500 mg bid during the last two weeks of acidified milk therapy. Oesophagogastroduodenoscopy and biopsies were performed at inclusion and repeated 4-8 weeks after the end of the treatment. H. pylori infection was confirmed by urease test and histology. H. pylori density and inflammation were scored using a modified Sydney classification. RESULTS: LC-1 ingestion induced a decrease in H. pylori density in the antrum (P= 0.02) and the corpus (P= 0.04). LC-1 also reduced inflammation and gastritis activity in the antrum (P= 0.02 and P= 0.01, respectively) and of activity in the corpus (P= 0.02). Clarithromycin eradicated H. pylori in 26% of the subjects; LC-1 did not improve the antibiotic effect. CONCLUSION: These results suggest that H. pylori infection and gastritis can be down-regulated by LC-1.
Keywords
Animals Anti-Bacterial Agents/therapeutic use Breath Tests Clarithromycin/therapeutic use Double-Blind Method Female Gastritis/*microbiology/*therapy Helicobacter Infections/*therapy *Helicobacter pylori Humans *Lactobacillus acidophilus Male Milk/*microbiology Pyloric Antrum/microbiology
Pubmed
Web of science
Create date
25/01/2008 15:58
Last modification date
20/08/2019 13:08
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