Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis

Details

Serval ID
serval:BIB_292820927DA6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis
Journal
Medical and Pediatric Oncology
Author(s)
Hopkins-Donaldson  S., Bodmer  J. L., Bourloud  K. B., Brognara  C. B., Tschopp  J., Gross  N.
ISSN
0098-1532 (Print)
Publication state
Published
Issued date
12/2000
Volume
35
Number
6
Pages
608-11
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
Background and Procedures NB-derived cell lines were tested for their sensitivity to apoptosis induced by the tumor-selective apoptotic ligand TRAIL. Noninvasive S-type cell lines are highly sensitive to TRAIL, whereas invasive N-type cell lines are resistant. RESULTS: Although both S- and N-type cell lines express TRAIL-R2, FADD, and caspases-3 and -10, only S-type cells express caspase-8. Reduced levels of caspase-8 protein were also observed in a stage IV NB tumor when compared to a ganglioneuroma. The caspase-8 gene is not deleted in either N-type NB cell lines or high-stage tumors, and expression can be induced by demethylation. CONCLUSIONS: Therefore, caspase-8 expression is silenced in malignant NB, which correlates to tumor severity and resistance to TRAIL-induced apoptosis.
Keywords
Apoptosis/*genetics Apoptosis Regulatory Proteins Caspase 8 Caspase 9 Caspases/*genetics *Gene Expression Regulation, Neoplastic Humans Membrane Glycoproteins/*genetics Neuroblastoma/*genetics TNF-Related Apoptosis-Inducing Ligand Tumor Cells, Cultured Tumor Necrosis Factor-alpha/*genetics
Pubmed
Web of science
Create date
24/01/2008 15:19
Last modification date
20/08/2019 13:08
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