Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis
Details
Serval ID
serval:BIB_292820927DA6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis
Journal
Medical and Pediatric Oncology
ISSN
0098-1532 (Print)
Publication state
Published
Issued date
12/2000
Volume
35
Number
6
Pages
608-11
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
Background and Procedures NB-derived cell lines were tested for their sensitivity to apoptosis induced by the tumor-selective apoptotic ligand TRAIL. Noninvasive S-type cell lines are highly sensitive to TRAIL, whereas invasive N-type cell lines are resistant. RESULTS: Although both S- and N-type cell lines express TRAIL-R2, FADD, and caspases-3 and -10, only S-type cells express caspase-8. Reduced levels of caspase-8 protein were also observed in a stage IV NB tumor when compared to a ganglioneuroma. The caspase-8 gene is not deleted in either N-type NB cell lines or high-stage tumors, and expression can be induced by demethylation. CONCLUSIONS: Therefore, caspase-8 expression is silenced in malignant NB, which correlates to tumor severity and resistance to TRAIL-induced apoptosis.
Keywords
Apoptosis/*genetics
Apoptosis Regulatory Proteins
Caspase 8
Caspase 9
Caspases/*genetics
*Gene Expression Regulation, Neoplastic
Humans
Membrane Glycoproteins/*genetics
Neuroblastoma/*genetics
TNF-Related Apoptosis-Inducing Ligand
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha/*genetics
Pubmed
Web of science
Create date
24/01/2008 16:19
Last modification date
20/08/2019 14:08