Metabolic programming in dendritic cells tailors immune responses and homeostasis.

Details

Serval ID
serval:BIB_28FD58401C9C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Metabolic programming in dendritic cells tailors immune responses and homeostasis.
Journal
Cellular & molecular immunology
Author(s)
Møller S.H., Wang L., Ho P.C.
ISSN
2042-0226 (Electronic)
ISSN-L
1672-7681
Publication state
Published
Issued date
03/2022
Peer-reviewed
Oui
Volume
19
Number
3
Pages
370-383
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
It is being increasingly acknowledged that immune cells depend on certain metabolic traits to perform their functions and that the extracellular environment can influence cell metabolism and vice versa. Dendritic cell (DC) subsets traffic through highly diverse environments from the bone marrow, where they develop, to the various peripheral tissues, where they differentiate and capture antigens, before they migrate to the lymph node to present antigens and prime T cells. It is plausible that DC subsets modulate their stimulatory abilities in response to unique metabolic programming. The metabolic requirements of DCs are just recently being discovered, and subset- and context-specific metabolic phenotypes in DCs are highly intertwined with DC functions. In this review, we present the current knowledge on the intrinsic and extrinsic determinants of DC metabolism, how they regulate DC function with examples from tumor biology and in interaction with the microbiota, and discuss how this can be applied therapeutically.
Keywords
Dendritic cells, Homeostasis, Immunometabolism, Microbiota, Tumor immunity
Pubmed
Web of science
Open Access
Yes
Create date
03/09/2021 18:13
Last modification date
29/03/2022 6:36
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