A new electrophysiological index for working memory load in humans.

Details

Serval ID
serval:BIB_288A97D6BF80
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A new electrophysiological index for working memory load in humans.
Journal
Neuroreport
Author(s)
Missonnier P., Leonards U., Gold G., Palix J., Ibáñez V., Giannakopoulos P.
ISSN
0959-4965
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
14
Number
11
Pages
1451-5
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Working memory, the ability to store and simultaneously manipulate information, is affected in several neuropsychiatric disorders which lead to severe cognitive and functional deficits. An electrophysiological marker for this process could help identify early cerebral function abnormalities. In subjects performing working memory-specific n-back tasks, event-related potential analysis revealed a positive-negative waveform (PNwm) component modulated in amplitude by working memory load. It occurs in the expected time range for this process, 140-280 ms after stimulus onset, superimposed on the classical P200 and N200 components. Independent Component Analysis extracted two functional components with latencies and topographical scalp distributions similar to the PNwm. Our results imply that the PNwm represents a new electrophysiological index for working memory load in humans.
Keywords
Adult, Brain Mapping, Electroencephalography, Electrophysiology, Evoked Potentials, Visual, Female, Humans, Male, Memory, Short-Term, Photic Stimulation, Principal Component Analysis, Reading
Pubmed
Web of science
Create date
19/11/2007 10:56
Last modification date
20/08/2019 14:08
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