Basal serum tryptase as risk assessment for severe Hymenoptera sting reactions in elderly.

Details

Serval ID
serval:BIB_285B851C6A1C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Basal serum tryptase as risk assessment for severe Hymenoptera sting reactions in elderly.
Journal
Allergy
Author(s)
Guenova E., Volz T., Eichner M., Hoetzenecker W., Caroli U., Griesinger G., Burow G., Mitev V., Biedermann T.
ISSN
1398-9995 (Electronic)
ISSN-L
0105-4538
Publication state
Published
Issued date
07/2010
Peer-reviewed
Oui
Volume
65
Number
7
Pages
919-923
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Epidemiologic studies suggest that elderly people are more prone to develop severe anaphylactic reactions. However, the exact cause for this phenomenon remains unclear.
To study the role of the serum tryptase as a diagnostic parameter for individual risk evaluation and its impact on the severity of allergic reactions in elderly people.
Two hundred and seventy-four consecutive patients visiting the Department of Dermatology, Tübingen, Germany, who were diagnosed with honeybee or wasp venom allergy, were included in the study.
Sting reaction severity increased with increased age and tryptase levels (P = 0.001 and P = 0.0003, respectively). Furthermore, we find not only a general increment in tryptase levels in elderly people (P = 0.0001) but also a continuous increase in tryptase concentrations even below the cut-off (11.4 microg/l) with increasing age (P = 0.0026).
Our data confirm serum tryptase as a risk factor for severe anaphylactic reaction to hymenoptera stings. Furthermore, we give first evidence that basal serum tryptase levels increase continuously with age and being an indicator for either increased mast cell load or reactivity this can at least partly be responsible for the observed aggravated allergic reactions in elderly people. As those patients are at increased risk for life-threatening anaphylactic reactions, it should be considered to adjust VIT especially in elderly patients with elevated tryptase levels as recommended for patients with mastocytosis by increasing venom doses during VIT and by considering its life-long continuation.
Keywords
Adolescent, Adult, Age Factors, Aged, Anaphylaxis/blood, Anaphylaxis/enzymology, Anaphylaxis/immunology, Animals, Arthropod Venoms/adverse effects, Arthropod Venoms/immunology, Female, Humans, Hymenoptera/immunology, Immunoglobulin E/blood, Insect Bites and Stings/blood, Insect Bites and Stings/enzymology, Insect Bites and Stings/immunology, Male, Middle Aged, Risk Factors, Skin Tests, Tryptases/blood
Pubmed
Web of science
Create date
27/08/2020 14:00
Last modification date
02/09/2020 5:26
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