Post‑COVID‑19 Syndrome in Outpatients: a Cohort Study.


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Article: article from journal or magazin.
Post‑COVID‑19 Syndrome in Outpatients: a Cohort Study.
Journal of general internal medicine
Desgranges F., Tadini E., Munting A., Regina J., Filippidis P., Viala B., Karachalias E., Suttels V., Haefliger D., Kampouri E., Van Singer M., Tschopp J., Rochat Stettler L., Schaad S., Brahier T., Hugli O., Mueller Y., Gouveia A., Opota O., Carron P.N., Guery B., Papadimitriou-Olivgeris M., Boillat-Blanco N.
Working group(s)
, the RegCOVID Research Group
1525-1497 (Electronic)
Publication state
In Press
Publication types: Journal Article
Publication Status: aheadofprint
After mild COVID-19, some outpatients experience persistent symptoms. However, data are scarce and prospective studies are urgently needed.
To characterize the post-COVID-19 syndrome after mild COVID-19 and identify predictors.
Outpatients with symptoms suggestive of COVID-19 with (1) PCR-confirmed COVID-19 (COVID-positive) or (2) SARS-CoV-2 negative PCR (COVID-negative).
Monocentric cohort study with prospective phone interview between more than 3 months to 10 months after initial visit to the emergency department and outpatient clinics.
Data of the initial visits were extracted from the electronic medical file. Predefined persistent symptoms were assessed through a structured phone interview. Associations between long-term symptoms and PCR results, as well as predictors of persistent symptoms among COVID-positive, were evaluated by multivariate logistic regression adjusted for age, gender, smoking, comorbidities, and timing of the survey.
The study population consisted of 418 COVID-positive and 89 COVID-negative patients, mostly young adults (median age of 41 versus 36 years in COVID-positive and COVID-negative, respectively; p = 0.020) and healthcare workers (67% versus 82%; p = 0.006). Median time between the initial visit and the phone survey was 150 days in COVID-positive and 242 days in COVID-negative patients. Persistent symptoms were reported by 223 (53%) COVID-positive and 33 (37%) COVID-negative patients (p = 0.006) and proportions were stable among the periods of the phone interviews. Overall, 21% COVID-positive and 15% COVID-negative patients (p = 0.182) attended care for this purpose. Four surveyed symptoms were independently associated with COVID-19: fatigue (adjusted odds ratio 2.14, 95% CI 1.04-4.41), smell/taste disorder (26.5, 3.46-202), dyspnea (2.81, 1.10-7.16), and memory impairment (5.71, 1.53-21.3). Among COVID-positive, female gender (1.67, 1.09-2.56) and overweight/obesity (1.67, 1.10-2.56) were predictors of persistent symptoms.
More than half of COVID-positive outpatients report persistent symptoms up to 10 months after a mild disease. Only 4 of 14 symptoms were associated with COVID-19 status. The symptoms and predictors of the post-COVID-19 syndrome need further characterization as this condition places a significant burden on society.
adult, cohort analysis, comorbidity, controlled study, dyspnea, emergency ward, female, gender, health care personnel, human, interview, long COVID, major clinical study, male, memory disorder, obesity, outpatient department, polymerase chain reaction, prospective study, smelling disorder, smoking, taste disorder, young adult, Post-COVID-19 syndrome, Post-acute COVID-19 syndrome
Web of science
Open Access
Create date
14/01/2022 14:45
Last modification date
09/04/2022 6:33
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