Treatment of liver metastases from uveal melanoma by combined surgery-chemotherapy.

Details

Serval ID
serval:BIB_2812324E6C45
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Treatment of liver metastases from uveal melanoma by combined surgery-chemotherapy.
Journal
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Author(s)
Salmon R.J., Levy C., Plancher C., Dorval T., Desjardins L., Leyvraz S., Pouillart P., Schlienger P., Servois V., Asselain B.
ISSN
0748-7983 (Print)
ISSN-L
0748-7983
Publication state
Published
Issued date
04/1998
Peer-reviewed
Oui
Volume
24
Number
2
Pages
127-130
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
AIMS: To investigate sporadic results demonstrating prolonged survival after surgical resection and/or intraarterial chemotherapy (IACH) for liver metastases from uveal melanoma.
METHODS: From December 1992 to March 1997 every patient with liver metastases from uveal melanoma was enrolled in a prospective study including: (1) aggressive surgical approach removing as much liver disease as possible; (2) implantation of an intraaterial catheter; (3) intraarterial chemotherapy for 6 months. 75 patients were enrolled: 38 men, 37 women, mean age 51 years (range: 18-72), mean time from initial diagnosis of uveal melanoma to liver metastases 37 months (ranged: 1-168).
RESULTS: Disseminated disease in both lobes was present in all but one patient. Macroscopically curative surgery was possible in 27.5%. Significant tumour reduction was performed in 49.3% and a simple biopsy was possible in 23.2%. Eight patients did not receive chemotherapy and died soon after. IACH included Fotemustine and/or DTIC-Platinum for 4-9 cycles. Overall median survival was 9 months; very similar to non-operated historical controls. In the 61 patients receiving complete treatment surgery plus chemotherapy, median survival improved to 10 months. When curative resection was possible, survival increased to 22 months (P < 0.001).
CONCLUSIONS: Aggressive surgical resection, when possible, appears to be the best method of improving survival of liver metastases from uveal melanoma. New drug combinations are also required to improve survival.
Keywords
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/administration & dosage, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Catheters, Indwelling, Chemotherapy, Adjuvant, Cisplatin/administration & dosage, Female, Humans, Infusions, Intra-Arterial, Liver Neoplasms/drug therapy, Liver Neoplasms/secondary, Male, Melanoma/drug therapy, Melanoma/secondary, Middle Aged, Nitrosourea Compounds/administration & dosage, Organophosphorus Compounds/administration & dosage, Prospective Studies, Survival Analysis, Treatment Outcome, Uveal Neoplasms/pathology
Pubmed
Web of science
Create date
28/01/2008 8:31
Last modification date
20/08/2019 13:07
Usage data