Reduced 11beta-hydroxysteroid dehydrogenase activity in patients with the nephrotic syndrome

Details

Serval ID
serval:BIB_280E80FA016E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reduced 11beta-hydroxysteroid dehydrogenase activity in patients with the nephrotic syndrome
Journal
Journal of Clinical Endocrinology and Metabolism
Author(s)
Vogt  B., Dick  B., N'Gankam  V., Frey  F. J., Frey  B. M.
ISSN
0021-972X (Print)
Publication state
Published
Issued date
02/1999
Volume
84
Number
2
Pages
811-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
Patients with the nephrotic syndrome (NS) exhibit abnormal renal sodium retention which cannot completely explained by a secondary hyperaldosteronism due to reduced renal perfusion. As an alternative mechanism to explain this phenomenon we postulate a cortisol-mediated mineralocorticoid effect as a consequence of a reduced activity of 11beta-hydroxysteroid dehydrogenase (11beta-HSD). A down-regulation of 11beta-HSD, i.e. of the shuttle of active to inactive glucocorticosteroids, has been shown to cause mineralocorticoid effects. Therefore we investigated the activity of 11beta-HSD by measuring the urinary ratio of (tetrahydrocortisol + 5alpha-tetrahydrocortisol)/tetrahydrocortisone [(THF+5alpha-THF)/THE] by gas-chromatography in 29 NS patients with biopsy-proven glomerulonephritis and 29 healthy control subjects. The ratio of (THF+5alpha-THF)/THE was higher in NS patients (median 1.49, range 0.45-4.07) than in the control subjects (0.98, 0.60-1.36; p<0.01). This ratio was increased as a consequence of a decreased urinary excretion rate of the cortisone metabolite, THE. The present data indicate that a reduced activity of 11beta-HSD is a new mechanism contributing to the exaggerated sodium retention in patients with the NS.
Keywords
11-beta-Hydroxysteroid Dehydrogenases Adult Aged Aged, 80 and over Female Humans Hydroxysteroid Dehydrogenases/*metabolism Male Middle Aged Nephrotic Syndrome/*enzymology/urine Tetrahydrocortisol/urine Tetrahydrocortisone/urine
Pubmed
Web of science
Create date
25/01/2008 13:03
Last modification date
20/08/2019 13:07
Usage data