Diagnostic Performance of PET or PET/CT Using <sup>18</sup>F-FDG Labeled White Blood Cells in Infectious Diseases: A Systematic Review and a Bivariate Meta-Analysis.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_27A41D0C07F2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diagnostic Performance of PET or PET/CT Using <sup>18</sup>F-FDG Labeled White Blood Cells in Infectious Diseases: A Systematic Review and a Bivariate Meta-Analysis.
Journal
Diagnostics
Author(s)
Meyer M., Testart N., Jreige M., Kamani C., Moshebah M., Muoio B., Nicod-Lalonde M., Schaefer N., Giovanella L., Prior J.O., Treglia G.
ISSN
2075-4418 (Print)
ISSN-L
2075-4418
Publication state
Published
Issued date
15/06/2019
Peer-reviewed
Oui
Volume
9
Number
2
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Diagnostic performance of positron emission tomography using white blood cells labeled with fluorine-18-fluorodeoxyglucose ( <sup>18</sup> F-FDG-WBC PET or PET/CT) in patients with suspicious infectious diseases has been evaluated in several studies; however, there is no consensus about the diagnostic accuracy of this method. Therefore, a systematic review and meta-analysis was carried out on this topic.
A comprehensive computer literature search screening PubMed/MEDLINE, Embase and Cochrane library databases through March 2019 was performed. Pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-), and diagnostic odds ratio (DOR) of <sup>18</sup> F-FDG-WBC PET or PET/CT in patients with infectious diseases were calculated.
Eight studies on the use of <sup>18</sup> F-FDG-WBC PET or PET/CT in suspicious infectious diseases were discussed in the systematic review. The meta-analysis of seven studies (236 patients) provided these pooled results on a per patient-based analysis: sensitivity was 86.3% [95% confidence interval (95%CI) 75-92.9%], specificity 92% (95%CI 79.8-97.1%), LR+ 6.6 (95%CI: 3.1-14.1), LR- 0.2 (95%CI: 0.12-0.33), DOR 43.5 (95%CI: 12.2-155). A statistically significant heterogeneity was not detected.
Despite limited literature data, <sup>18</sup> F-FDG-WBC PET or PET/CT demonstrated a good diagnostic accuracy for the diagnosis of infectious diseases; nevertheless, larger studies are needed.
Keywords
18F-FDG, PET, infection, leukocytes, meta-analysis, white blood cells
Pubmed
Open Access
Yes
Create date
24/06/2019 17:48
Last modification date
02/09/2019 12:22
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