Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.

Details

Serval ID
serval:BIB_277BDAC7A7CE
Type
Article: article from journal or magazin.
Collection
Publications
Title
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.
Journal
Nature Genetics
Author(s)
McMahon F.J., McMahon F.J., Akula N., Schulze T.G., Muglia P., Tozzi F., Detera-Wadleigh S.D., Steele C.J., Breuer R., Strohmaier J., Wendland J.R., Mattheisen M., Mühleisen T.W., Maier W., Nöthen M.M., Cichon S., Farmer A., Vincent J.B., Holsboer F., Preisig M., Rietschel M.
Working group(s)
Bipolar Disorder Genome Study (BiGS) Consortium
ISSN
1546-1718[electronic], 1061-4036[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
42
Number
2
Pages
128-131
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The major mood disorders, which include bipolar disorder and major depressive disorder (MDD), are considered heritable traits, although previous genetic association studies have had limited success in robustly identifying risk loci. We performed a meta-analysis of five case-control cohorts for major mood disorder, including over 13,600 individuals genotyped on high-density SNP arrays. We identified SNPs at 3p21.1 associated with major mood disorders (rs2251219, P = 3.63 x 10(-8); odds ratio = 0.87; 95% confidence interval, 0.83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD.
Keywords
Chromosomes, Human, Pair 3/genetics, Genetic Loci/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Mood Disorders/genetics, Polymorphism, Single Nucleotide/genetics
Pubmed
Web of science
Create date
19/02/2010 11:18
Last modification date
20/08/2019 14:06
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